Publications | FengGao Lab @ SYSU

Journal Article 2026 Advanced Science

Cell-Selective Delivery of RIBOTACs via an Anti-EGFR Nanobody for Pancreatic Cancer Treatment

Tianli Luo^†, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang Ma, Feng GAO, Xin Wang^*

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Journal Article 2026 Frontiers in Endocrinology

Real-world performance of open-source large language models in diabetes diagnosis

Shu-Ting YANG^†, Sujie Liu^†, Yuxi Ma^†, Bao-Wen GAI, Junwei Liu, Liansheng Wang^*, Feng GAO^*, Zhiguang Zhou^*

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Journal Article 2026 CGH

INTELCAPE: A Deep Learning-Powered System for Automated, High-Accuracy Crohn's Disease Diagnosis via Capsule Endoscopy

De-Jun FAN^†, Yize Mao^†, Feng Liang^†, Zheng Liu^†, Huayu Li^†, Jian Tang, Yanan Liu, Mingjie Wang, Yuting Qian, Jie Chen, Neng Wang, Tao Yang, Shuangyi Tan, Guanbin Li^*, Feng GAO^*, Jiancong Hu^*, Xiaojian Wu^*

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Journal Article 2026 Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chu-Ling HU^†, Du CAI^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang LI, Min-Yi LV, Bao-Wen GAI, Chong Chen, Xinxin Huang, Run-Xian WANG, Xiao-Jian Wu^*, Peishan Hu^*, Feng GAO^*

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Journal Article 2026 Cell Death & Disease

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Chong Chen^†, Du CAI^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chu-Ling HU, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng GAO, Xiaojian Wu^*, Peishan Hu^*

Journal Article 2026 Diagnostics

Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

Bao-Wen GAI^†, Xin DUAN, Cheng-Hang LI, Chu-Ling HU, Min-Yi LV, Jia-Xin LEI, Run-Xian WANG, Feng GAO^*, Du CAI^*

Journal Article 2025 Cancer Science

Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Du CAI^†, Ming-Ru MAI^†, Ren-De HUANG^†, Hao-Ning QI, Xingzhi Feng, Qianling Gao, Yin-Meng ZHANG, Cheng-Hang LI, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng GAO^*

Journal Article 2025 Cell Genomics

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC

Haitao Xiang^†, Xiangyu Guan^†, Yaohua Wei^†, Shuzhen Luo^†, Haibo Zhang^†, Fanyu Bu, Yixin Yan, Yunyun Fu, Yijian Li, Qumiao Xu, Penghui Lin, Dongbing Liu, Xinlan Zhou, Feng GAO, Tai Chen, Guangjun Nie, Kui Wu, Ying Gu, Longqi Liu, Ziqing Ye^*, Xiaojian Wu^*, Ruifang Zhao^*, Siqi Liu^*, Xuan Dong^*

Conference Paper 2025 MICCAI

FSA-Net: Fractal-driven Synergistic Anatomy-aware Network for Segmenting White Line of Toldt in Laparoscopic Images

Ke-Cheng WU^†, Zhaohu Xing, Zerong Cai, Feng GAO, Wenxue Li, Lei Zhu^*

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Conference Paper 2025 MICCAI

Bridging Knowledge Discrepancy in Retinal Image Analysis through Federated Multi-Task Learning

Jing Yang^†, Yuxi Ma, Jin-Gang Yu, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang^*, Liansheng Wang^*

Code

Conference Paper 2025 MICCAI

Accurate Boundary Alignment and Realism Enhancement for Colonoscopic Polyp Image-Mask Pair Generation

Riyu Qiu^†, Kun Xia, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang, Yinran Chen^*, Liansheng Wang^*

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Journal Article 2025 iScience

A plasma metabolite-based test to detect minimal residual disease in post-surgery patients with colorectal cancer

Zhengran Zhou^†, Richard Mortensen^†, Peishan Hu^†, Bo Jin, Xiao-Bin Zheng, Xiao Li, James Schilling, C. James Chou, Karl G. Sylvester, Yanghai Cong, Xiaojian Wu, Feng GAO^*, Xuefeng B. Ling^*, Xuanhui Liu^*

Journal Article 2025 NAR

PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers

Ren-De HUANG^†, Jiang Li^†, Qi Cao^†, Lixia Wang^†, Zhixiong Shao, Haochun Yang, Xinlei Zhang, Chuanlai Yang, Xiangya Kong, Qiuyue Gu, Jianmin Wu, Tsan-Yu Chiu, Penghu Lian^*, Kui Wu^*, Feng GAO^*, Zhongxu Zhu^*

Code Project DOI

Journal Article 2025 IJS

Immunological Microenvironment Differences Between Left and Right Colon Cancer: Dynamic Interactions of CASC15+KLK6+ Epithelial Subpopulation with T Cells and Mast Cells

Yibin Zhao^†, Hao Liu^†, Yu Wang, Jie Shen, Yang Le, Peiyuan Li, Yuxiang Zhao^*, Feng GAO^*, Wei Cui^*

Journal Article 2025 Clin Transl Disc

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

Chong-Xiang GAO^†, Du CAI, Jianguang Qiu^*, Feng GAO^*

Journal Article 2025 Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Jing Yang^†, Du CAI^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-Ao Wang, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng GAO^*, Xiaojian Wu^*

Journal Article 2025 Nature Communications

Personalized risk stratification in colorectal cancer via PIANOS system

Du CAI^†, Hao-Ning QI^†, Qiuxia Yang^†, Huayu Li^†, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Xu Zhang, Yize Mao^*, Feng GAO^*, Xiaojian Wu^*

Journal Article 2025 BMC Cancer

Certain pMMR colorectal cancer patients should undergo additional MSI-PCR testing to reduce the risk of misdiagnosing MSI-H and Lynch syndrome

Jing-Lin HUANG^†, Liang Xu^†, Yacheng Cai, Xiaoli Tan, Hanjie Lin, Zhiting Chen, Chao WANG, Weihao Deng, Xinhui Fu^*

Source Document DOI

Journal Article 2025 ESMO Gastrointest Oncol

Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics

Jia Ke^†, Ying Li^†, Lin Qi^†, Xiang Li, Wei Wang, Sanne Ten Hoorn, Yin Zhu, Hao Huang, Feng GAO, Louis Vermeulen, Xin Wang^*

Journal Article 2025 Advanced Science

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Feng GAO^†, Junxiang Ding^†, Bao-Wen GAI^†, Du CAI^†, Chu-Ling HU, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^*

Journal Article 2025 TVC

HADiff: hierarchy aggregated diffusion model for pathology image segmentation

Xuefeng Zhang^†, Bin Yan, Zhaohu Xing, Feng GAO, Yuandong Tao, Zhenyan Han, Weiming Wang^*, Lei Zhu^*

Code DOI

Journal Article 2025 Genomics Proteomics Bioinformatics

Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis

Junwei Liu^†, Xiaoping Cen^†, Chenxin Yi, Feng-Ao Wang, Junxiang Ding, Jinyu Cheng, Qinhua Wu, Bao-Wen GAI, Yiwen Zhou, Ruikun He, Feng GAO^*, Yixue Li^*

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