Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Early-onset colorectal cancer (EOCRC) is clinically aggressive and lacks precise treatment stratification tools. This work integrates multi-omics data from 2961 patients and reveals distinct senescence-driven EOCRC subtypes with markedly different prognosis and tumor microenvironment characteristics. The proposed EO-Senscore model quantifies senescence states and helps identify patients more likely to benefit from immunotherapy, chemotherapy, or anti-senescence strategies.