Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and leads data analysis for the colorectal cancer program of the International Cancer Genome Consortium's Accelerating Research in Genomic Oncology initiative (ICGC-ARGO). Trained in computer science, cancer biology, and bioinformatics, he develops explainable and multimodal artificial intelligence for cancer research and clinical care. His lab uses colorectal cancer as a flagship setting, with work spanning disease mechanisms, medical imaging, clinical prediction, intelligent surgery, and AI systems that support complex medical and research tasks under expert supervision. The long-term goal is to improve healthcare quality and efficiency, expand access to expert care, and keep evidence, professional judgment, and human responsibility explicit. This work contributes to the technical foundations of the AI-Native Future Hospital.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and BioinformaticsCity University of Hong Kong & Cornell University2015 - 2018
Visiting Student in Computer Science and Electronic EngineeringKumamoto University2007 - 2008
BEng in Computer Science and TechnologyShandong University2005 - 2009

Lab highlights

Highlighted publications

2026CGH

INTELCAPE: A Deep Learning-Powered System for Automated, High-Accuracy Crohn's Disease Diagnosis via Capsule Endoscopy

2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

2025NAR

PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers

All related publications

Journal ArticleJul 16, 2026Advanced Science

Cell-Selective Delivery of RIBOTACs via an Anti-EGFR Nanobody for Pancreatic Cancer Treatment

Tianli Luo^†, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang Ma, Feng Gao, Xin Wang^*

Source document DOI

PreprintJul 9, 2026medRxiv

In Vivo Spatial Transcriptomics for Bleeding-free Profiling Human Internal Organs

Conference PaperMay 1, 2026Gastroenterology

UNRAVELING THE IMPACT OF INSOMNIA ON COLORECTAL CANCER: MICROBIOME DYSBIOSIS, IMMUNOSUPPRESSIVE MICROENVIRONMENT, AND THERAPEUTIC IMPLICATIONS

Yinmeng Zhang, Du Cai, Jiahui Zhao, He Zhu, Yan Xia, Baowen Gai, Haoning Qi, Chuling Hu, Rende Huang, Mingru Mai, Nan Zhang, Xiao-Jian Wu, Hong Xu, Feng Gao

Journal ArticleMar 25, 2026Frontiers in Endocrinology

Real-world performance of open-source large language models in diabetes diagnosis

Shuting Yang^†, Sujie Liu^†, Yuxi Ma^†, Baowen Gai, Junwei Liu, Liansheng Wang^*, Feng Gao^*, Zhiguang Zhou^*

Source document DOI

Journal ArticleMar 19, 2026CGH

INTELCAPE: A Deep Learning-Powered System for Automated, High-Accuracy Crohn's Disease Diagnosis via Capsule Endoscopy

De-Jun Fan^†, Yize Mao^†, Feng Liang^†, Zheng Liu^†, Huayu Li^†, Jian Tang, Yanan Liu, Mingjie Wang, Yuting Qian, Jie Chen, Neng Wang, Tao Yang, Shuangyi Tan, Guanbin Li^*, Feng Gao^*, Jiancong Hu^*, Xiaojian Wu^*

Code Source document DOI

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Source document DOI

PreprintMar 10, 2026medRxiv

CT4CMS: Preoperative Computed Tomography-Based Consensus Molecular Subtyping Prediction in Colorectal Cancer Using Interpretable Deep Learning

Xianrui Zhang^†, Xiuping Nie^†, Tan Wu, Du Cai, Hua Xue, Lin Qi, Yijuan Wang, Yi Cao, Lingli He, Yinghan Zhang, Yuanyao Cheng, Haotian Wang, Xiaoyu Wang, Enyu Li, Yue Dong^*, Feng Gao^*, Xin Wang^*

Journal ArticleJan 21, 2026Cell Death & Disease

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Chong Chen^†, Du Cai^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng Gao, Xiaojian Wu^*, Peishan Hu^*

Journal ArticleJan 14, 2026Diagnostics

Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

Baowen Gai^†, Xin Duan, Chenghang Li, Chuling Hu, Minyi Lv, Jiaxin Lei, Runxian Wang, Feng Gao^*, Du Cai^*

Journal ArticleDec 4, 2025Cancer Science

Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Du Cai^†, Mingru Mai^†, Rende Huang^†, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng Gao^*

Journal ArticleNov 13, 2025Cell Genomics

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC

Haitao Xiang^†, Xiangyu Guan^†, Yaohua Wei^†, Shuzhen Luo^†, Haibo Zhang^†, Fanyu Bu, Yixin Yan, Yunyun Fu, Yijian Li, Qumiao Xu, Penghui Lin, Dongbing Liu, Xinlan Zhou, Feng Gao, Tai Chen, Guangjun Nie, Kui Wu, Ying Gu, Longqi Liu, Ziqing Ye^*, Xiaojian Wu^*, Ruifang Zhao^*, Siqi Liu^*, Xuan Dong^*

Conference PaperSep 20, 2025MICCAI

Accurate Boundary Alignment and Realism Enhancement for Colonoscopic Polyp Image-Mask Pair Generation

Riyu Qiu, Kun Xia, Feng Gao, Shuting Yang, Du Cai, Jiacheng Wang, Yinran Chen^*, Liansheng Wang^*

Conference PaperSep 20, 2025MICCAI

FSA-Net: Fractal-driven Synergistic Anatomy-aware Network for Segmenting White Line of Toldt in Laparoscopic Images

Kecheng Wu, Zhaohu Xing, Zerong Cai, Feng Gao, Wenxue Li, Lei Zhu^*

Conference PaperSep 20, 2025MICCAI

Bridging Knowledge Discrepancy in Retinal Image Analysis through Federated Multi-Task Learning

Jing Yang, Yuxi Ma, Jin-Gang Yu, Feng Gao, Shuting Yang, Du Cai, Jiacheng Wang^*, Liansheng Wang^*

Journal ArticleSep 19, 2025iScience

A plasma metabolite-based test to detect minimal residual disease in post-surgery patients with colorectal cancer

Zhengran Zhou^†, Richard Mortensen^†, Peishan Hu^†, Bo Jin, Xiao-bin Zheng, Xiao Li, James Schilling, C. James Chou, Karl G. Sylvester, Yanghai Cong, Xiaojian Wu, Feng Gao^*, Xuefeng B. Ling^*, Xuanhui Liu^*

Journal ArticleSep 14, 2025NAR

PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers

Ren-de Huang^†, Jiang Li^†, Qi Cao^†, Lixia Wang^†, Zhixiong Shao, Haochun Yang, Xinlei Zhang, Chuanlai Yang, Xiangya Kong, Qiuyue Gu, Jianmin Wu, Tsan-Yu Chiu, Penghu Lian^*, Kui Wu^*, Feng Gao^*, Zhongxu Zhu^*

Code Project DOI

Journal ArticleSep 10, 2025IJS

Immunological Microenvironment Differences Between Left and Right Colon Cancer: Dynamic Interactions of CASC15+KLK6+ Epithelial Subpopulation with T Cells and Mast Cells

Yibin Zhao^†, Hao Liu^†, Yu Wang, Jie Shen, Yang Le, Peiyuan Li, Yuxiang Zhao^*, Feng Gao^*, Wei Cui^*

Journal ArticleSep 3, 2025Clin Transl Disc

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

Chong-xiang Gao^†, Du Cai, Jianguang Qiu^*, Feng Gao^*

Journal ArticleSep 1, 2025Translational Cancer Research

Integrating prognosis-related genes with immune-related gene signature for development and validation of a survival stratification model for early-stage colorectal cancer

Zhengran Zhou, Xiaobin Zheng, Zerong Cai, Yufeng Chen, Weiqiang You, Zhaoliang Yu, Xi Chen, Yifeng Zou, Xiaojian Wu, Feng Gao, Xuanhui Liu

Journal ArticleJul 23, 2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Jing Yang^†, Du Cai^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-ao Wang, Cheng-hang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng Gao^*, Xiaojian Wu^*

Showing the 20 most recent of 124 related publications.