Chu-Ling HU

Postdoc

The Sixth Affiliated Hospital of Sun Yat-sen University

Biography

Dr. Chu-Ling HU is a postdoctoral researcher at the Sixth Affiliated Hospital of Sun Yat-sen University. He completed his doctoral training in surgery in 2026 and studies colorectal cancer through bioinformatics, deep learning, and clinically useful AI model development.

Research Interests

Colorectal Cancer
Artificial Intelligence

Education

Postdoctoral ResearcherThe Sixth Affiliated Hospital of Sun Yat-sen University2026 - Present
Doctor of Medicine in SurgerySun Yat-sen University2021 - 2026
Bachelor of Medicine in Clinical MedicineSun Yat-sen University2016 - 2021

Lab highlights

Highlighted publications

2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

2025Nature Communications

Personalized risk stratification in colorectal cancer via PIANOS system

All related publications

Conference PaperMay 1, 2026Gastroenterology

UNRAVELING THE IMPACT OF INSOMNIA ON COLORECTAL CANCER: MICROBIOME DYSBIOSIS, IMMUNOSUPPRESSIVE MICROENVIRONMENT, AND THERAPEUTIC IMPLICATIONS

Yinmeng Zhang, Du Cai, Jiahui Zhao, He Zhu, Yan Xia, Baowen Gai, Haoning Qi, Chuling Hu, Rende Huang, Mingru Mai, Nan Zhang, Xiao-Jian Wu, Hong Xu, Feng Gao

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Source document DOI

Journal ArticleJan 21, 2026Cell Death & Disease

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Chong Chen^†, Du Cai^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng Gao, Xiaojian Wu^*, Peishan Hu^*

Journal ArticleJan 14, 2026Diagnostics

Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

Baowen Gai^†, Xin Duan, Chenghang Li, Chuling Hu, Minyi Lv, Jiaxin Lei, Runxian Wang, Feng Gao^*, Du Cai^*

Journal ArticleJul 23, 2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Jing Yang^†, Du Cai^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-ao Wang, Cheng-hang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleJul 16, 2025Nature Communications

Personalized risk stratification in colorectal cancer via PIANOS system

Du Cai^†, Haoning Qi^†, Qiuxia Yang^†, Huayu Li^†, Cheng-hang Li, Chuling Hu, Baowen Gai, Xu Zhang, Yize Mao^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleMar 7, 2025Advanced Science

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Feng Gao^†, Junxiang Ding^†, Baowen Gai^†, Du Cai^†, Chuling Hu, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^*

Journal ArticleSep 1, 2024International Journal of Surgery

Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study

Jia-Xin Lei^†, Runxian Wang^†, Chuling Hu, Xiaoying Lou, Min-Yi Lv, Cheng-hang Li, Baowen Gai, Xiao-Jian Wu^*, Ruoxu Dou^*, Du Cai^*, Feng Gao^*

Journal ArticleJun 26, 2023MedComm

Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

Min-Yi Lv^†, Du Cai^†, Cheng-Hang Li^†, Junguo Chen^†, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan^*, Xiaojian Wu^*, Xiaosheng He^*, Feng Gao^*

Conference PaperMay 1, 2023Gastroenterology

Senescence-Based Colorectal Cancer Subtyping Reveals Distinct Molecular Characteristics and Therapeutic Strategies

Min-Yi Lv, Du Cai, Cheng-Hang Li, Junguo Chen, Guanman Li, Chuling Hu, Baowen Gai, Jia-xin Lei, Ping Lan, Feng Gao, Xiaosheng He

Journal ArticleApr 1, 2023Cancer Medicine

An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer

Du Cai^†, Wei Wang, Min-Er Zhong, Dejun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xin Duan, Xiao-Jian Wu^*, Feng Gao^*

Journal ArticleSep 7, 2022Frontiers in Genetics

Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature

Chuling Hu^†, Du Cai, Min-Er Zhong, Dejun Fan, Cheng-Hang Li, Min-Yi Lv, Ze-Ping Huang, Wei Wang, Xiao-Jian Wu, Feng Gao^*

Conference PaperJun 1, 2022Journal of Clinical Oncology

A tumor immune microenvironment-related lncRNA signature for the prognosis and immunotherapeutic sensitivity prediction in colorectal cancer.

Chuling Hu, Du Cai, Min-Er Zhong, De-jun Fan, Cheng-Hang Li, Min-Yi Lv, Ze-Ping Huang, Wei Wang, Xiaojian Wu, Feng Gao

Journal ArticleMay 12, 2022Frontiers in Genetics

Multi-size deep learning based preoperative computed tomography signature for prognosis prediction of colorectal cancer

Cheng-Hang Li^†, Du Cai, Min-Er Zhong, Min-Yi Lv, Ze-Ping Huang, Qiqi Zhu, Chuling Hu, Haoning Qi, Xiaojian Wu, Feng Gao^*

Journal ArticleMar 11, 2022Frontiers in Genetics

DNA Repair–Related Gene Signature in Predicting Prognosis of Colorectal Cancer Patients

Min-yi Lv^†, Wei Wang^†, Min-Er Zhong^†, Du Cai, De-jun Fan, Cheng-hang Li, Wei-Bin Kou, Ze-ping Huang, Xin Duan, Chuling Hu, Qiqi Zhu, Xiao-sheng He, Feng Gao^*

Conference PaperMay 20, 2021Journal of Clinical Oncology

Deep learning to identify a gene signature associated with molecular subtypes that predicts prognosis in colorectal cancer.

Du Cai, Wei Wang, Min-Er Zhong, De-jun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xin Duan, Xiaojian Wu, Feng Gao

Conference PaperMay 20, 2021Journal of Clinical Oncology

A model combing an immune-related genes signature and an extracellular matrix-related genes signature in predicting prognosis of left-and right-sided colon cancer

Min-Er Zhong, Du Cai, De-jun Fan, Wei Wang, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xiaojian Wu, Feng Gao

Conference PaperMay 20, 2021Journal of Clinical Oncology

Identifying an immune-related gene-pair for prognosis prediction of metastatic colorectal cancer.

Qiqi Zhu, Du Cai, Wei Wang, Min-Er Zhong, De-jun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Min-Yi Lv, Chuling Hu, Xin Duan, Xiaojian Wu, Feng Gao