Du CAI

Postdoc

Sun Yat-sen University

Biography

Dr. Du Cai, a postdoctoral researcher in the Department of Surgery at the Sixth Affiliated Hospital of Sun Yat-sen University, utilizes explainable AI (XAI) techniques and large foundation models in medical imaging and digital pathology to drive translational research in colorectal cancer.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Doctor of Medicine in SurgerySun Yat-sen University2018 - 2023
Bachelor of Medicine in Clinical MedicineSun Yat-sen University2013 - 2018

Lab highlights

Highlighted publications

2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

2025TMI

SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation

All related publications

Conference PaperMay 1, 2026Gastroenterology

UNRAVELING THE IMPACT OF INSOMNIA ON COLORECTAL CANCER: MICROBIOME DYSBIOSIS, IMMUNOSUPPRESSIVE MICROENVIRONMENT, AND THERAPEUTIC IMPLICATIONS

Yinmeng Zhang, Du Cai, Jiahui Zhao, He Zhu, Yan Xia, Baowen Gai, Haoning Qi, Chuling Hu, Rende Huang, Mingru Mai, Nan Zhang, Xiao-Jian Wu, Hong Xu, Feng Gao

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Source document DOI

PreprintMar 10, 2026medRxiv

CT4CMS: Preoperative Computed Tomography-Based Consensus Molecular Subtyping Prediction in Colorectal Cancer Using Interpretable Deep Learning

Xianrui Zhang^†, Xiuping Nie^†, Tan Wu, Du Cai, Hua Xue, Lin Qi, Yijuan Wang, Yi Cao, Lingli He, Yinghan Zhang, Yuanyao Cheng, Haotian Wang, Xiaoyu Wang, Enyu Li, Yue Dong^*, Feng Gao^*, Xin Wang^*

Journal ArticleJan 21, 2026Cell Death & Disease

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Chong Chen^†, Du Cai^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng Gao, Xiaojian Wu^*, Peishan Hu^*

Journal ArticleJan 14, 2026Diagnostics

Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

Baowen Gai^†, Xin Duan, Chenghang Li, Chuling Hu, Minyi Lv, Jiaxin Lei, Runxian Wang, Feng Gao^*, Du Cai^*

Journal ArticleDec 4, 2025Cancer Science

Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Du Cai^†, Mingru Mai^†, Rende Huang^†, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng Gao^*

Conference PaperSep 20, 2025MICCAI

Accurate Boundary Alignment and Realism Enhancement for Colonoscopic Polyp Image-Mask Pair Generation

Riyu Qiu, Kun Xia, Feng Gao, Shuting Yang, Du Cai, Jiacheng Wang, Yinran Chen^*, Liansheng Wang^*

Conference PaperSep 20, 2025MICCAI

Bridging Knowledge Discrepancy in Retinal Image Analysis through Federated Multi-Task Learning

Jing Yang, Yuxi Ma, Jin-Gang Yu, Feng Gao, Shuting Yang, Du Cai, Jiacheng Wang^*, Liansheng Wang^*

Journal ArticleSep 3, 2025Clin Transl Disc

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

Chong-xiang Gao^†, Du Cai, Jianguang Qiu^*, Feng Gao^*

Journal ArticleJul 23, 2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Jing Yang^†, Du Cai^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-ao Wang, Cheng-hang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleJul 18, 2025TMI

SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation

Zhaohu Xing^†, Tian Ye, Yijun Yang, Du Cai, Baowen Gai, Xiao-Jian Wu^*, Feng Gao^*, Lei Zhu^*

Journal ArticleJul 16, 2025Nature Communications

Personalized risk stratification in colorectal cancer via PIANOS system

Du Cai^†, Haoning Qi^†, Qiuxia Yang^†, Huayu Li^†, Cheng-hang Li, Chuling Hu, Baowen Gai, Xu Zhang, Yize Mao^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleMar 7, 2025Advanced Science

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Feng Gao^†, Junxiang Ding^†, Baowen Gai^†, Du Cai^†, Chuling Hu, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^*

Journal ArticleDec 27, 2024Gland Surgery

Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer

Zhen Xie^†, Du Cai^†, Runyi Ye, Zhen Shan, Ying Lin, Feng Gao^*, Nan Shao^*, Xiaying Kuang^*

Journal ArticleSep 1, 2024International Journal of Surgery

Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study

Jia-Xin Lei^†, Runxian Wang^†, Chuling Hu, Xiaoying Lou, Min-Yi Lv, Cheng-hang Li, Baowen Gai, Xiao-Jian Wu^*, Ruoxu Dou^*, Du Cai^*, Feng Gao^*

Journal ArticleNov 8, 2023Scientific Reports

A prognostic model for ovarian neoplasms established by an integrated analysis of 1580 transcriptomic profiles

Yanjiao Hua^†, Du Cai, Cole Andrea Shirley, Sien Mo, Ruyun Chen, Feng Gao, Fangying Chen^*

Journal ArticleJun 26, 2023MedComm

Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

Min-Yi Lv^†, Du Cai^†, Cheng-Hang Li^†, Junguo Chen^†, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan^*, Xiaojian Wu^*, Xiaosheng He^*, Feng Gao^*

Conference PaperJun 1, 2023International Digestive Disease Forum

Immunological profiling of human colorectal cancer defines four distinct molecular subtypes

Weiqiang You, Du Cai, Minyi Lv, Peishan Hu, Feng Gao, Xiaojian Wu

Conference PaperMay 1, 2023Gastroenterology

Senescence-Based Colorectal Cancer Subtyping Reveals Distinct Molecular Characteristics and Therapeutic Strategies

Min-Yi Lv, Du Cai, Cheng-Hang Li, Junguo Chen, Guanman Li, Chuling Hu, Baowen Gai, Jia-xin Lei, Ping Lan, Feng Gao, Xiaosheng He

Journal ArticleApr 1, 2023Cancer Medicine

An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer

Du Cai^†, Wei Wang, Min-Er Zhong, Dejun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xin Duan, Xiao-Jian Wu^*, Feng Gao^*

Showing the 20 most recent of 34 related publications.