article journal

Journal ArticleJul 16, 2026Advanced Science

Cell-Selective Delivery of RIBOTACs via an Anti-EGFR Nanobody for Pancreatic Cancer Treatment

Tianli Luo^†, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang Ma, Feng Gao, Xin Wang^*

Journal ArticleMar 25, 2026Frontiers in Endocrinology

Real-world performance of open-source large language models in diabetes diagnosis

Shuting Yang^†, Sujie Liu^†, Yuxi Ma^†, Baowen Gai, Junwei Liu, Liansheng Wang^*, Feng Gao^*, Zhiguang Zhou^*

Journal ArticleMar 19, 2026CGH

INTELCAPE: A Deep Learning-Powered System for Automated, High-Accuracy Crohn's Disease Diagnosis via Capsule Endoscopy

De-Jun Fan^†, Yize Mao^†, Feng Liang^†, Zheng Liu^†, Huayu Li^†, Jian Tang, Yanan Liu, Mingjie Wang, Yuting Qian, Jie Chen, Neng Wang, Tao Yang, Shuangyi Tan, Guanbin Li^*, Feng Gao^*, Jiancong Hu^*, Xiaojian Wu^*

Code Source document DOI

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Journal ArticleJan 21, 2026Cell Death & Disease

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Chong Chen^†, Du Cai^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng Gao, Xiaojian Wu^*, Peishan Hu^*

Journal ArticleJan 14, 2026Diagnostics

Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

Baowen Gai^†, Xin Duan, Chenghang Li, Chuling Hu, Minyi Lv, Jiaxin Lei, Runxian Wang, Feng Gao^*, Du Cai^*

Journal ArticleDec 4, 2025Cancer Science

Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Du Cai^†, Mingru Mai^†, Rende Huang^†, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng Gao^*

Journal ArticleNov 13, 2025Cell Genomics

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC

Haitao Xiang^†, Xiangyu Guan^†, Yaohua Wei^†, Shuzhen Luo^†, Haibo Zhang^†, Fanyu Bu, Yixin Yan, Yunyun Fu, Yijian Li, Qumiao Xu, Penghui Lin, Dongbing Liu, Xinlan Zhou, Feng Gao, Tai Chen, Guangjun Nie, Kui Wu, Ying Gu, Longqi Liu, Ziqing Ye^*, Xiaojian Wu^*, Ruifang Zhao^*, Siqi Liu^*, Xuan Dong^*

Journal ArticleSep 19, 2025iScience

A plasma metabolite-based test to detect minimal residual disease in post-surgery patients with colorectal cancer

Zhengran Zhou^†, Richard Mortensen^†, Peishan Hu^†, Bo Jin, Xiao-bin Zheng, Xiao Li, James Schilling, C. James Chou, Karl G. Sylvester, Yanghai Cong, Xiaojian Wu, Feng Gao^*, Xuefeng B. Ling^*, Xuanhui Liu^*

Journal ArticleSep 14, 2025NAR

PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers

Ren-de Huang^†, Jiang Li^†, Qi Cao^†, Lixia Wang^†, Zhixiong Shao, Haochun Yang, Xinlei Zhang, Chuanlai Yang, Xiangya Kong, Qiuyue Gu, Jianmin Wu, Tsan-Yu Chiu, Penghu Lian^*, Kui Wu^*, Feng Gao^*, Zhongxu Zhu^*

Code Project DOI

Journal ArticleSep 10, 2025IJS

Immunological Microenvironment Differences Between Left and Right Colon Cancer: Dynamic Interactions of CASC15+KLK6+ Epithelial Subpopulation with T Cells and Mast Cells

Yibin Zhao^†, Hao Liu^†, Yu Wang, Jie Shen, Yang Le, Peiyuan Li, Yuxiang Zhao^*, Feng Gao^*, Wei Cui^*

Journal ArticleSep 3, 2025Clin Transl Disc

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

Chong-xiang Gao^†, Du Cai, Jianguang Qiu^*, Feng Gao^*

Journal ArticleSep 1, 2025Translational Cancer Research

Integrating prognosis-related genes with immune-related gene signature for development and validation of a survival stratification model for early-stage colorectal cancer

Zhengran Zhou, Xiaobin Zheng, Zerong Cai, Yufeng Chen, Weiqiang You, Zhaoliang Yu, Xi Chen, Yifeng Zou, Xiaojian Wu, Feng Gao, Xuanhui Liu

Journal ArticleJul 23, 2025Advanced Science

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Jing Yang^†, Du Cai^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-ao Wang, Cheng-hang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleJul 18, 2025TMI

SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation

Zhaohu Xing^†, Tian Ye, Yijun Yang, Du Cai, Baowen Gai, Xiao-Jian Wu^*, Feng Gao^*, Lei Zhu^*

Code DOI

Journal ArticleJul 16, 2025Nature Communications

Personalized risk stratification in colorectal cancer via PIANOS system

Du Cai^†, Haoning Qi^†, Qiuxia Yang^†, Huayu Li^†, Cheng-hang Li, Chuling Hu, Baowen Gai, Xu Zhang, Yize Mao^*, Feng Gao^*, Xiaojian Wu^*

Journal ArticleJul 1, 2025BMC Cancer

Certain pMMR colorectal cancer patients should undergo additional MSI-PCR testing to reduce the risk of misdiagnosing MSI-H and Lynch syndrome

Jinglin Huang^†, Liang Xu^†, Yacheng Cai, Xiaoli Tan, Hanjie Lin, Zhiting Chen, Chao Wang, Weihao Deng, Xinhui Fu^*

Journal ArticleJun 9, 2025ESMO Gastrointest Oncol

Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics

Jia Ke^†, Ying Li^†, Lin Qi^†, Xiang Li, Wei Wang, Sanne Ten Hoorn, Yin Zhu, Hao Huang, Feng Gao, Louis Vermeulen, Xin Wang^*

Journal ArticleMar 7, 2025Advanced Science

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Feng Gao^†, Junxiang Ding^†, Baowen Gai^†, Du Cai^†, Chuling Hu, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^*

Journal ArticleMar 1, 2025TVC

HADiff: hierarchy aggregated diffusion model for pathology image segmentation

Xuefeng Zhang, Bin Yan, Zhaohu Xing, Feng Gao, Yuandong Tao, Zhenyan Han, Weiming Wang^*, Lei Zhu^*

Code DOI

Journal ArticleFeb 27, 2025Genomics Proteomics Bioinformatics

Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis

Junwei Liu^†, Xiaoping Cen^†, Chenxin Yi, Feng-Ao Wang, Junxiang Ding, Jinyu Cheng, Qinhua Wu, Baowen Gai, Yiwen Zhou, Ruikun He, Feng Gao^*, Yixue Li^*

PMID Trial Registration Dataset DOI

Journal ArticleFeb 1, 2025Gut

Liquid biopsy to identify Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma: the EMERALD multicentre study

Jinsei Miyoshi^†, Alessandro Mannucci^†, Marco Scarpa, Feng Gao, Shusuke Toden, Timothy Whitsett, Landon J Inge, Ross M Bremner, Tetsuji Takayama, Yulan Cheng, Teodoro Bottiglieri, Iris D Nagetaal, Martha J Shrubsole, Ali H Zaidi, Xin Wang, Helen G Coleman, Lesley A Anderson, Stephen J Meltzer, Ajay Goel^*

Journal ArticleDec 30, 2024Scientific Reports

Anatomic association between the gastrocolic trunk of Henle and right colic artery by high-quality CT venography

Xinzhe Zhao^†, Hongda Zhang, Hengyu Zhao, Decan Kong, Weijie Zeng, Feng Gao, Xiaochun Meng, Jia Ke^*

Journal ArticleDec 27, 2024Gland Surgery

Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer

Zhen Xie^†, Du Cai^†, Runyi Ye, Zhen Shan, Ying Lin, Feng Gao^*, Nan Shao^*, Xiaying Kuang^*

Journal ArticleNov 19, 2024Nature Communications

Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening

Feng Guo^†, Xianglin Ji^†, Chuxiao Xiong, Hailiang Sun, Zhenghua Liang, Richard Yan-Do, Baowen Gai, Feng Gao, Linfeng Huang, Zhongping Li, Becki Yi Kuang, Peng Shi^*

Journal ArticleSep 19, 2024Journal of Clinical Pathology

Head-to-head comparative study: evaluating three panels for MSI-PCR testing in patients with colorectal and gastric cancer

Xinhui Fu^†, Jinglin Huang^†, Xinjuan Fan, Chao Wang, Weihao Deng, Xiaoli Tan, Zhiting Chen, Yacheng Cai, Hanjie Lin, Liang Xu, Jiaxin Zou, Huanmiao Zhan, Shuhui Huang, Yan Huang^*

Source document

Journal ArticleSep 1, 2024International Journal of Surgery

Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study

Jia-Xin Lei^†, Runxian Wang^†, Chuling Hu, Xiaoying Lou, Min-Yi Lv, Cheng-hang Li, Baowen Gai, Xiao-Jian Wu^*, Ruoxu Dou^*, Du Cai^*, Feng Gao^*

Journal ArticleAug 25, 2024Journal of Practical Medicine / Shiyong Yixue Zazhi

A new vision of diabetes classification： A shift from clinical manifestation to etiological molecular mechanism

Shuting Yang^†, Shuoming Luo, Zhiguang Zhou^*

Journal ArticleJun 6, 2024Genome Biology

TMO-Net: an explainable pretrained multi-omics model for multi-task learning in oncology

Feng-Ao Wang^†, Zhenfeng Zhuang^†, Feng Gao^†, Ruikun He, Shaoting Zhang, Liansheng Wang^*, Junwei Liu^*, Yixue Li^*

Journal ArticleApr 12, 2024IEEE Transactions on Medical Imaging

Structure Embedded Nucleus Classification for Histopathology Images

Wei Lou^†, Xiang Wan, Guanbin Li, Xiaoying Lou, Cheng-Hang Li, Feng Gao, Haofeng Li^*

Journal ArticleApr 5, 2024International Journal of Cancer

Prognosis and immunotherapy efficacy in dMMR&MSS colorectal cancer patients and an MSI status predicting model

Xinhui Fu^†, Jinglin Huang^†, Junling Zhu, Xinjuan Fan, Chao Wang, Weihao Deng, Xiaoli Tan, Zhiting Chen, Yacheng Cai, Hanjie Lin, Guannan Wang, Ning Zhang, Yongmin Zhu, Ji Chen, Huanmiao Zhan, Shuhui Huang, Yongzhen Fang, Yuhua Li^*, Yan Huang^*

Source document

Journal ArticleFeb 27, 2024Frontiers in Medicine

Editorial: Clinical risk assessment and intervention of gastrointestinal tumors driven by big-data

Nan Zhang^*, Wei Wang, Xin Gao, Feng Gao

Journal ArticleDec 20, 2023Neuron

Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair

Ngan Pan Bennett Au^†, Tan Wu, Xinyu Chen, Feng Gao, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H Geschwind, Giovanni Coppola, Xin Wang, Chi Him Eddie Ma

Journal ArticleDec 1, 2023Diseases of the Colon & Rectum

A Longitudinal MRI-Based Artificial Intelligence System to Predict Pathological Complete Response After Neoadjuvant Therapy in Rectal Cancer: A Multicenter Validation Study

Jia Ke^†, Cheng Jin^†, Jinghua Tang^†, Haimei Cao^†, Songbing He^†, Peirong Ding, Xiaofeng Jiang, Hengyu Zhao, Wuteng Cao, Xiaochun Meng, Feng Gao, Ping Lan, Ruijiang Li^*, Xiaojian Wu^*

Journal ArticleNov 8, 2023Scientific Reports

A prognostic model for ovarian neoplasms established by an integrated analysis of 1580 transcriptomic profiles

Yanjiao Hua^†, Du Cai, Cole Andrea Shirley, Sien Mo, Ruyun Chen, Feng Gao, Fangying Chen^*

Journal ArticleOct 1, 2023iScience

Deep learning-derived spatial organization features on histology images predicts prognosis in colorectal liver metastasis patients after hepatectomy

Lin Qi^†, Jie-ying Liang^†, Zhong-wu Li, Shao-yan Xi, Yu-ni Lai, Feng Gao, Xian-rui Zhang, De-shen Wang, Ming-tao Hu, Yi Cao, Li-Jian Xu, Ronald C K Chan, Bao-Cai Xing, Xin Wang^*, Yu-Hong Li^*

Journal ArticleSep 1, 2023Zhonghua Nei Ke Za Zhi (Chinese Journal of Internal Medicine)

Application of the Chinese Expert Consensus on Diabetes Classification in Clinical Practice

Shuting Yang^†, Chao Deng, Bobo He, Xi Chen, Xia Li, Zhiguang Zhou^*

Journal ArticleJul 1, 2023Cancer Immunology, Immunotherapy

The landscape of objective response rate of anti-PD-1/L1 monotherapy across 31 types of cancer: a system review and novel biomarker investigating

Yize Mao^†, Hui Xie^†, Min-yi Lv^†, Qiuxia Yang, Zeyu Shuang, Feng Gao, Shengping Li^*, Lina Zhu^*, Wei Wang^*

Journal ArticleJun 26, 2023MedComm

Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

Min-Yi Lv^†, Du Cai^†, Cheng-Hang Li^†, Junguo Chen^†, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan^*, Xiaojian Wu^*, Xiaosheng He^*, Feng Gao^*

Journal ArticleApr 1, 2023Cancer Medicine

An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer

Du Cai^†, Wei Wang, Min-Er Zhong, Dejun Fan, Xuanhui Liu, Cheng-Hang Li, Ze-Ping Huang, Qiqi Zhu, Min-Yi Lv, Chuling Hu, Xin Duan, Xiao-Jian Wu^*, Feng Gao^*

Journal ArticleApr 1, 2023Heliyon

MiR-423-5p is a novel endogenous control for the quantification of circulating miRNAs in human esophageal squamous cell carcinoma

Yuanyuan Guo^†, Xuantong Zhou, Feng Gao, Minjie Wang, Qi Yang, Xin Li, Zhihua Liu, Aiping Luo^*

Journal ArticleMar 24, 2023Frontiers in Molecular Biosciences

Editorial: Medical knowledge-assisted machine learning technologies in individualized medicine

Feng Gao, William C. Cho, Xin Gao, Wei Wang

Journal ArticleJan 30, 2023Frontiers in Immunology

Association between genetically predicted leukocyte telomere length and non-scarring alopecia: a two-sample Mendelian randomization study

Yicheng Li^†, Shuting Yang, Minjun Liao, Zijun Zheng, Mengyao Li, Xuerong Wei, Mengqian Liu, Lei Yang^*

Journal ArticleJan 1, 2023Frontiers in Molecular Biosciences

Medical knowledge-assisted machine learning technologies in individualized medicine

Feng Gao^†, William C Cho, Xin Gao, Wei Wang^*

Journal ArticleDec 8, 2022Journal of Translational Medicine

CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study

Min-Er Zhong^†, Xin Duan^†, Ma-yi-di-li Ni-jia-ti, Haoning Qi, Dongwei Xu, Du Cai, Cheng-Hang Li, Zeping Huang, Qiqi Zhu, Feng Gao^*, Xiaojian Wu^*

Journal ArticleSep 7, 2022Frontiers in Genetics

Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature

Chuling Hu^†, Du Cai, Min-Er Zhong, Dejun Fan, Cheng-Hang Li, Min-Yi Lv, Ze-Ping Huang, Wei Wang, Xiao-Jian Wu, Feng Gao^*

Journal ArticleAug 1, 2022Medical Image Analysis

Segmentation only uses sparse annotations: Unified weakly and semi-supervised learning in medical images

Feng Gao^†*, Minhao Hu^†, Min-Er Zhong^†, Shixiang Feng, Xuwei Tian, Xiaochun Meng, Ze-ping Huang, Min-yi Lv, Tao Song, Xiaofan Zhang^*, Xiangguang Zou^*, Xiaojian Wu^*

Journal ArticleJun 30, 2022Frontiers in Oncology

A transcription factor signature can identify the CMS4 subtype and stratify the prognostic risk of colorectal cancer

Min-Er Zhong^†, Ze-Ping Huang^†, Xun Wang^†, Du Cai, Cheng-Hang Li, Feng Gao^*, Xiao-Jian Wu^*, Wei Wang^*

Journal ArticleMay 12, 2022Frontiers in Genetics

Multi-size deep learning based preoperative computed tomography signature for prognosis prediction of colorectal cancer

Cheng-Hang Li^†, Du Cai, Min-Er Zhong, Min-Yi Lv, Ze-Ping Huang, Qiqi Zhu, Chuling Hu, Haoning Qi, Xiaojian Wu, Feng Gao^*

Journal ArticleApr 14, 2022European Radiology

The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study

Qian Cai^†, Yi-ze Mao^†, Si-qi Dai^†, Feng Gao^†, Qian Xiao, Wan-ming Hu, Tao Qin, Qiu-xia Yang, Zhao-zhou Li, Du Cai, Min-Er Zhong, Ke-feng Ding^*, Xiaojian Wu^*, Rong Zhang^*

Journal ArticleMar 11, 2022Frontiers in Genetics

DNA Repair–Related Gene Signature in Predicting Prognosis of Colorectal Cancer Patients

Min-yi Lv^†, Wei Wang^†, Min-Er Zhong^†, Du Cai, De-jun Fan, Cheng-hang Li, Wei-Bin Kou, Ze-ping Huang, Xin Duan, Chuling Hu, Qiqi Zhu, Xiao-sheng He, Feng Gao^*

Journal ArticleFeb 11, 2022Molecular Cancer

A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study

Jinsei Miyoshi^†, Zhongxu Zhu^†, Aiping Luo^†, Shusuke Toden^†, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal M. Parker, Minjie Wang, Feng Gao, Ali H. Zaidi, Hideo Baba, Yasuhiro Kodera, Yongping Cui, Xin Wang^*, Zhihua Liu^*, Ajay Goel^*

Journal ArticleFeb 4, 2022Oncogene

Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence

Tongtong Kan^†, Shupeng Zhang, Shengtao Zhou, Ya Zhang, Yun Zhao, Yinghua Gao, Tao Zhang, Feng Gao, Xin Wang, Linjie Zhao, Mengsu Yang^*

Journal ArticleJan 11, 2022Frontiers in Genetics

Dissecting Cellular Heterogeneity Based on Network Denoising of scRNA-seq Using Local Scaling Self-Diffusion

Xin Duan^†, Wei Wang, Minghui Tang, Feng Gao^*, Xu-dong Lin^*

Journal ArticleNov 25, 2021Frontiers in Genetics

Identification of an autophagy-related gene signature for the prediction of prognosis in early-stage colorectal cancer

Xu-tao Lin^†, Qiu-ning Wu, Si Qin, De-jun Fan, Min-yi Lv, Xi Chen, Jia-wei Cai, Jing-rong Weng, Yi-feng Zou, Yu-ming Rong^*, Feng Gao^*

Journal ArticleOct 30, 2021Molecular Medicine

Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis

Yu-feng Chen^†, Zhao-liang Yu^†, Min-yi Lv^†, Ze-rong Cai, Yi-feng Zou, Ping Lan^*, Xiao-jian Wu^*, Feng Gao^*

Journal ArticleAug 1, 2021Clinical Cancer Research

OCaMIR—a noninvasive, diagnostic signature for early-stage ovarian cancer: a multi-cohort retrospective and prospective study

Raju Kandimalla^†, Wei Wang, Fan Yu, Nianxin Zhou, Feng Gao, Monique Spillman, Lucie Moukova, Ondrej Slaby, Bodour Salhia, Shengtao Zhou^*, Xin Wang^*, Ajay Goel^*

Journal ArticleJun 22, 2021Frontiers in Physiology

An interpretable computer-aided diagnosis method for periodontitis from panoramic radiographs

Haoyang Li^†, Juexiao Zhou, Yi Zhou, Qiang Chen, Yangyang She, Feng Gao, Ying Xu, Jieyu Chen, Xin Gao^*

Journal ArticleJun 15, 2021Frontiers in Medicine

Genome-Wide analysis reveals hypoxic microenvironment is associated with immunosuppression in poor survival of stage II/III colorectal cancer patients

Yu-feng Chen^†, Zhao-liang Yu, Min-yi Lv, Bin Zheng, Ying-xin Tan, Jia Ke, Xuan-hui Liu, Ze-rong Cai, Yi-feng Zou, Ping Lan^*, Xiao-jian Wu^*, Feng Gao^*

Journal ArticleMar 25, 2021Nature Communications

Predicting treatment response from longitudinal images using multi-task deep learning

Cheng Jin^†, Heng Yu^†, Jia Ke^†, Peirong Ding^†, Yongju Yi, Xiaofeng Jiang, Xin Duan, Jinghua Tang, Daniel T. Chang, Xiaojian Wu^*, Feng Gao^*, Ruijiang Li^*

Journal ArticleMar 11, 2021Molecular Oncology

A novel cell-free DNA methylation-based model improves the early detection of colorectal cancer

Xianrui Wu^†, Yunfeng Zhang^†, Tuo Hu, Xiaowen He, Yifeng Zou, Qiling Deng, Jia Ke, Lei Lian, Xiaosheng He, Dezhi Zhao, Xuyu Cai, Zhiwei Chen, Xiaojian Wu, Jian-Bing Fan^*, Feng Gao^*, Ping Lan^*

Journal ArticleFeb 11, 2021Medicine in Omics

Identification of prognostic spatial organization features in colorectal cancer microenvironment using deep learning on histopathology images

Lin Qi^†, Jia Ke, Zhaoliang Yu, Yi Cao, Yuni Lai, Yufeng Chen, Feng Gao^*, Xin Wang^*

Journal ArticleJan 23, 2021The Journal of Clinical Endocrinology & Metabolism

Response to Letter to the Editor from Knobler et al:“Validation of the Swedish Diabetes Regrouping Scheme in Adult-Onset Diabetes in China”

Xia Li^†, Shuting Yang, Xilin Yang^*, Zhiguang Zhou^*

Journal ArticleJan 7, 2021Cancer Cell International

Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer

Zhao-Liang Yu^†, Yu-Feng Chen^†, Bin Zheng, Ze-Rong Cai, Yi-Feng Zou, Jia Ke, Ping Lan, Feng Gao^*, Xiao-Jian Wu^*

Journal ArticleJan 7, 2021Frontiers in Molecular Biosciences

A metabolism-related radiomics signature for predicting the prognosis of colorectal cancer

Du Cai^†, Xin Duan^†, Wei Wang, Ze-Ping Huang, Qiqi Zhu, Min-Er Zhong, Min-Yi Lv, Cheng-Hang Li, Wei-Bin Kou, Xiao-Jian Wu^*, Feng Gao^*

Journal ArticleAug 18, 2020The Journal of Clinical Endocrinology & Metabolism

Validation of the Swedish diabetes re-grouping scheme in adult-onset diabetes in China

Xia Li^†, Shuting Yang^†, Chuqing Cao, Xiang Yan, Lei Zheng, Lanbo Zheng, Jiarui Da, Xiaohan Tang, Linong Ji, Xilin Yang^*, Zhiguang Zhou^*

Journal ArticleAug 14, 2020European Journal of Surgical Oncology

Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients

Jia Ke^†, Xuan-hui Liu^†, Xiao-feng Jiang, Zhen He, Jian Xiao, Bin Zheng, Yu-feng Chen, Ze-rong Cai, Xiao-bin Zheng, Yi-feng Zou, Ping Lan, Xiao-jian Wu^*, Feng Gao^*

Journal ArticleAug 1, 2020Journal of Computational Biology

Multiomics-based colorectal cancer molecular subtyping using local scaling network fusion

Xin Duan^†, Kejun Wang, Jia Ke, Ping Lan, Feng Gao^*, Xiaojian Wu^*

Journal ArticleJul 27, 2020Nucleic Acids Research

Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers

Journal ArticleJul 1, 2020Cellular Signalling

Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor

Asif Rashid^†, Xin Duan^†, Feng Gao^†, Mengsu Yang^*, Andrew Yen^*

Journal ArticleJun 1, 2020Endocrine

GLP-1 receptor agonists and pancreatic safety concerns in type 2 diabetic patients: data from cardiovascular outcome trials

Chuqing Cao^†, Shuting Yang, Zhiguang Zhou^*

Journal ArticleMar 24, 2020Oncotarget

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation

Asif Rashid^†, Xin Duan^†, Feng Gao^†, Mengsu Yang, Andrew Yen^*

Journal ArticleMar 1, 2020Annals of Translational Medicine

Analysis of potential hub genes involved in the pathogenesis of Chinese type 1 diabetic patients

Shuting Yang^†, Chuqing Cao, Zhiguo Xie, Zhiguang Zhou^*

Journal ArticleFeb 1, 2020Annals of Translational Medicine

Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer

Shu-Biao Ye^†, Yi-Kan Cheng^†, Jian-Cong Hu^†, Feng Gao^*, Ping Lan^*

Journal ArticleFeb 1, 2020Phytotherapy Research

The potential application of Cordyceps in metabolic-related disorders

Chuqing Cao^†, Shuting Yang, Zhiguang Zhou^*

Journal ArticleJan 17, 2020Cancer Cell International

Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma

Yangyang She^†, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jieyu Chen, Feng Gao^*, Silian Fang^*

Journal ArticleJan 1, 2020Kidney and Blood Pressure Research

Obesity-related glomerulopathy: a latent change in obesity requiring more attention

Shuting Yang^†, Chuqing Cao, Tuo Deng, Zhiguang Zhou^*

Journal ArticleDec 4, 2019Journal of Computational Biology

Multiomics-Based Colorectal Cancer Molecular Subtyping Using Local Scaling Network Fusion

Xin Duan^†, Kejun Wang, Jia Ke, Ping Lan, Feng Gao^*, Xiaojian Wu^*

Journal ArticleNov 1, 2019Endocrine

GLP-1 receptor agonists and risk of cancer in type 2 diabetes: an updated meta-analysis of randomized controlled trials

Chuqing Cao^†, Shuting Yang, Zhiguang Zhou^*

Journal ArticleSep 23, 2019Cancer Cell International

A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients

Yi-Feng Zou^†, Yu-Ming Rong^†, Ying-Xin Tan^†, Jian Xiao, Zhao-Liang Yu, Yu-Feng Chen, Jia Ke, Cheng-Hang Li, Xi Chen, Xiao-Jian Wu, Ping Lan, Xu-Tao Lin, Feng Gao^*

Journal ArticleSep 1, 2019Hepatology

Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms

Hui Chen^†, Feng Gao^†, Mian He^†, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W.-H. Chan, Xin Wang^*, Nathalie Wong^*

Journal ArticleAug 28, 2019OncoTargets and Therapy

An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma

Liuyan Zhang^†, Ping Zhu^†, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang^*, Feng Gao^*, Peng Shu^*

Journal ArticleAug 16, 2019Oncogenesis

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification

Feng Gao^†, Wei Wang, Miaomiao Tan, Lina Zhu, Yuchen Zhang, Evelyn Fessler, Louis Vermeulen, Xin Wang^*

Journal ArticleJul 1, 2019Medicine

An immune-related gene signature predicts prognosis of gastric cancer

Bitao Jiang^†, Qingsen Sun^†, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang^*, Feng Gao^*, Peng Shu^*

Journal ArticleJun 17, 2019Nature Communications

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Journal ArticleJun 1, 2019Gastroenterology

Gene expression signature in surgical tissues and endoscopic biopsies identifies high-risk T1 colorectal cancers

Raju Kandimalla^†, Tsuyoshi Ozawa^†, Feng Gao^†, Xin Wang^*, Ajay Goel^*, T1 Colorectal Cancer Study Group

Journal ArticleMay 1, 2019Annals of Surgery

Genome-wide discovery of a novel gene-expression signature for the identification of lymph node metastasis in esophageal squamous cell carcinoma

Fuminori Sonohara^†, Feng Gao^†, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang^*, Ajay Goel^*

Journal ArticleMay 1, 2019npj Precision Oncology

RNAMethyPro: a biologically conserved signature of N6-methyladenosine regulators for predicting survival at pan-cancer level

Raju Kandimalla^†, Feng Gao^†, Ying Li^†, Hao Huang, Jia Ke, Xin Deng, Linjie Zhao, Shengtao Zhou, Ajay Goel^*, Xin Wang^*

Journal ArticleApr 1, 2019Seminars in Cancer Biology

Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities

Wei Wang^†, Raju Kandimalla^†, Hao Huang^†, Lina Zhu, Ying Li, Feng Gao, Ajay Goel, Xin Wang^*

Journal ArticleMar 1, 2019EBioMedicine

A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer

Daisuke Izumi^†, Feng Gao^†, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba^*, Ajay Goel^*

Journal ArticleDec 20, 2018Leukemia and Lymphoma

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Journal ArticleSep 14, 2018PLoS ONE

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Journal ArticleMar 1, 2018Gastroenterology

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