Topic

immunotherapy

5 publications

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Source document DOI

Research

MotifCC

MotifCC integrates gene expression, mutation and methylation data to identify CRC immune subtypes. It connects a WNT-active, immune-cold subtype to experiments testing WNT inhibition as a candidate approach to improve antitumour immunity.

Journal ArticleNov 13, 2025Cell Genomics

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC

Haitao Xiang^†, Xiangyu Guan^†, Yaohua Wei^†, Shuzhen Luo^†, Haibo Zhang^†, Fanyu Bu, Yixin Yan, Yunyun Fu, Yijian Li, Qumiao Xu, Penghui Lin, Dongbing Liu, Xinlan Zhou, Feng Gao, Tai Chen, Guangjun Nie, Kui Wu, Ying Gu, Longqi Liu, Ziqing Ye^*, Xiaojian Wu^*, Ruifang Zhao^*, Siqi Liu^*, Xuan Dong^*

DOI

Journal ArticleSep 3, 2025Clin Transl Disc

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

Chong-xiang Gao^†, Du Cai, Jianguang Qiu^*, Feng Gao^*

DOI

Journal ArticleApr 5, 2024International Journal of Cancer

Prognosis and immunotherapy efficacy in dMMR&MSS colorectal cancer patients and an MSI status predicting model

Xinhui Fu^†, Jinglin Huang^†, Junling Zhu, Xinjuan Fan, Chao Wang, Weihao Deng, Xiaoli Tan, Zhiting Chen, Yacheng Cai, Hanjie Lin, Guannan Wang, Ning Zhang, Yongmin Zhu, Ji Chen, Huanmiao Zhan, Shuhui Huang, Yongzhen Fang, Yuhua Li^*, Yan Huang^*

Source document