Topic

multi omics

4 publications

Journal ArticleMar 11, 2026Cancer Letters

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

Chuling Hu^†, Du Cai^†, Weiqiang You^†, Zhengran Zhou^†, Junwei Liu, Cheng-Hang Li, Min-Yi Lv, Bao-Wen Gai, Chong Chen, Xinxin Huang, Run Xian Wang, Xiao-Jian Wu^*, Peishan Hu^*, Feng Gao^*

Source document DOI

Research

MotifCC

MotifCC integrates gene expression, mutation and methylation data to identify CRC immune subtypes. It connects a WNT-active, immune-cold subtype to experiments testing WNT inhibition as a candidate approach to improve antitumour immunity.

Research

PIANOS

Clinical risk assessment needs to work for an individual sample across platforms. PIANOS uses within-sample pathway rankings to stratify CRC prognosis and examine biological and treatment-response differences between risk groups.

Research

TMO-Net

Can a representation learned from multiple omics datasets transfer to new tasks? TMO-Net pretrains on four omics modalities from 8,174 patients across 32 cancer types, then adapts to classification, prognosis and drug-response modelling.