Overview
Current prognostic biomarkers for colorectal cancer often break down when cohorts, sequencing platforms, or preprocessing pipelines change. PIANOS addresses that translational bottleneck with a single-sample classifier that works on pathway rankings rather than fragile absolute measurements.
The system stratifies patients into clinically meaningful risk groups without cohort-wide normalization, making it much more suitable for real-world deployment. Beyond outcome prediction, PIANOS also reveals treatment-sensitive biological differences across subgroups, positioning the project as a bridge between transcriptomic modeling and actionable clinical decision support.
Validated across large international cohorts, PIANOS demonstrates that robust molecular stratification can be both technically rigorous and operationally practical.