International Journal of Surgery: TLS heterogeneity reveals prognosis and therapy opportunities in colorectal cancer
Our team reported in International Journal of Surgery that tertiary lymphoid structure heterogeneity can define clinically meaningful colorectal cancer subgroups.
The study integrated multi-omics data, digital pathology, and clinicopathological information to characterize distinct TLS patterns and derive a quantitative TLSscore for patient stratification.
Key points:
- Identified three TLS patterns in colorectal cancer with distinct immune, stromal, and prognostic features.
- Developed a nine-gene TLSscore for individual-level risk and treatment stratification.
- Suggested lower TLSscore may align with immunotherapy benefit, while higher TLSscore may favor adjuvant chemotherapy.