The potential application of Cordyceps in metabolic-related disorders
Changes in the global economy resulted in sedentary lifestyle and excessive calorie intake, increasing the incidence of metabolic diseases, which subsequently became a universal …
Chuqing Cao
Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer
**Background:** Metastatic colorectal cancer (mCRC) is a heterogeneous disease. Predictive biomarkers are in great demand to optimize patient selection at high risk for death and …
Shu-Biao Ye
Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma
**Background:** Immune-related genes (IRGs) were linked to the prognosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to identify the effects of an …
Yangyang She
Obesity-related glomerulopathy: a latent change in obesity requiring more attention
**Background:** Obesity has become a major public health problem, and the prevalence of kidney diseases has increased in parallel. Among kidney diseases caused by metabolic …
Multiomics-Based Colorectal Cancer Molecular Subtyping Using Local Scaling Network Fusion
Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular properties. Tremendous works for CRC molecular subtyping are mainly based on gene expression profiling, …
A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients
**Background:** The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a …
Yi-Feng Zou
Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms
Alternative splicing (AS) allows generation of cell type-specific mRNA transcripts and contributes to hallmarks of cancer. Genome-wide analysis for AS in human hepatocellular …
Hui Chen
An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma
**Background:** Ovarian cancer has the highest death rate of all fatal gynecological cancers. Increasing evidence has depicted the correlation between serous ovarian carcinoma …
Liuyan Zhang