Journal Article

Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients

**Aim:** Immune-related genes are associated with the prognosis of colorectal cancer (CRC) patients. The aim of this study was to evaluate the impact of an immune-related gene …

Multiomics-based colorectal cancer molecular subtyping using local scaling network fusion

Xin DUAN

• Aug 1, 2020 • 1 min read

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Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers

Hippo-YAP signaling pathway functions in early lineage differentiation of pluripotent stem cells, but the detailed mechanisms remain elusive. We found that knockout (KO) of Mst1 …

Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor

All-trans retinoic acid (ATRA)-based differentiation therapy has been unsuccessful in treating t(15;17) negative acute myeloid leukemia (AML) patients, motivating interest in …

GLP-1 receptor agonists and pancreatic safety concerns in type 2 diabetic patients: data from cardiovascular outcome trials

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation

Analysis of potential hub genes involved in the pathogenesis of Chinese type 1 diabetic patients

Shu-Ting YANG

• Mar 1, 2020 • 1 min read

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The potential application of Cordyceps in metabolic-related disorders

Changes in the global economy resulted in sedentary lifestyle and excessive calorie intake, increasing the incidence of metabolic diseases, which subsequently became a universal …

Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer

**Background:** Metastatic colorectal cancer (mCRC) is a heterogeneous disease. Predictive biomarkers are in great demand to optimize patient selection at high risk for death and …

Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma

**Background:** Immune-related genes (IRGs) were linked to the prognosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to identify the effects of an …