Journal Article

Genome-Wide analysis reveals hypoxic microenvironment is associated with immunosuppression in poor survival of stage II/III colorectal cancer patients

**Background:** Hypoxia is associated with a poorer clinical outcome and resistance to chemotherapy in solid tumors; identifying hypoxic-related colorectal cancer (CRC) and …

Yu-Feng Chen

Predicting treatment response from longitudinal images using multi-task deep learning

Radiographic imaging is routinely used to evaluate treatment response in solid tumors. Current imaging response metrics do not reliably predict the underlying biological response. …

Cheng Jin

A novel cell-free DNA methylation-based model improves the early detection of colorectal cancer

Screening for early-stage disease is vital for reducing colorectal cancer (CRC)-related mortality. Methylation of circulating tumor DNA has been previously used for various types …

Xianrui Wu

Identification of prognostic spatial organization features in colorectal cancer microenvironment using deep learning on histopathology images

**Background:** The ecological diversity in the tumor microenvironment influences cancer progression and clinical outcomes of patients. However, the complexity of cellular and …

Lin Qi

Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer

**Background:** Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with stem cell property. Increased evidence suggest that CSCs could be responsible for …

Zhao-Liang Yu

A metabolism-related radiomics signature for predicting the prognosis of colorectal cancer

**Background:** Radiomics refers to the extraction of a large amount of image information from medical images, which can provide decision support for clinicians. In this study, we …

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Du CAI

Validation of the Swedish diabetes re-grouping scheme in adult-onset diabetes in China

**Context:** This study applied the Swedish novel data-driven classification in Chinese newly diagnosed diabetic patients and validated its adoptability. **Objective:** This study …

Xia Li

Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients

**Aim:** Immune-related genes are associated with the prognosis of colorectal cancer (CRC) patients. The aim of this study was to evaluate the impact of an immune-related gene …

Jia Ke