Journal Article

Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer (CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, …

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Min-Yi LV

An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer

**Background:** Debates exist on the treatment decision of the stage II/III colorectal cancer (CRC) due to the insufficiency of the current TNM stage‐based risk stratification …

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Du CAI

Editorial: Medical knowledge-assisted machine learning technologies in individualized medicine

Machine learning (ML), a powerful tool for mining quantitative disease features in large quantities of medical data, is arguably the most important method for extracting, …

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Feng GAO

Association between genetically predicted leukocyte telomere length and non-scarring alopecia: a two-sample Mendelian randomization study

**Background:** The most commonly acknowledged non-scarring alopecia are androgenetic alopecia (AGA) and alopecia areata (AA). Previous studies have revealed various risk factors …

Yicheng Li

CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study

**Background:** This study aimed to develop a radiogenomic prognostic prediction model for colorectal cancer (CRC) by investigating the biological and clinical relevance of …

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Min-Er ZHONG

Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature

Long non-coding RNAs (lncRNAs) remodel the tumor immune microenvironment (TIME) by regulating the functions of tumor-infiltrating immune cells. It remains uncertain the way that …

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Chu-Ling HU

Segmentation only uses sparse annotations: Unified weakly and semi-supervised learning in medical images

Since segmentation labeling is usually time-consuming and annotating medical images requires professional expertise, it is laborious to obtain a large-scale, high-quality annotated …

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Feng GAO

A transcription factor signature can identify the CMS4 subtype and stratify the prognostic risk of colorectal cancer

**Background:** Colorectal cancer (CRC) is a heterogeneous disease, and current classification systems are insufficient for stratifying patients with different risks. This study …

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Min-Er ZHONG