Journal Article

Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics

Background: Young-onset colorectal cancer (CRC), affecting individuals <50 years of age, presents a significant health threat worldwide. The molecular and clinical characteristics …

Jia Ke

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion models based on artificial …

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Feng GAO

HADiff: hierarchy aggregated diffusion model for pathology image segmentation

The pathologists grade cancers by identifying the morphology of tumor areas, whereas this manual implementation is time-consuming and expensive. The most recent methods deploy …

Xuefeng Zhang

Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis

The rapid development of biological and medical examination methods has vastly expanded personal biomedical information, including molecular, cellular, image, and electronic health …

Junwei Liu

Liquid biopsy to identify Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma: the EMERALD multicentre study

**Background**: There is no clinically relevant serological marker for the early detection of oesophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's oesophagus (BE). …

Jinsei Miyoshi

SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation

The Transformer architecture has demonstrated remarkable results in 3D medical image segmentation due to its capability of modeling global relationships. However, it poses a …

Zhaohu Xing

Anatomic association between the gastrocolic trunk of Henle and right colic artery by high-quality CT venography

In hepatic flexure and transverse colon cancer surgeries, mobilizing the right mesocolon and precisely dissecting the gastrocolic trunk of Henle (GTH) are crucial. Previous …

Xinzhe Zhao

Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer

**Background:** Luminal B breast cancer is routinely treated with chemotherapy and endocrine therapy. However, its sensitivity to treatment remains heterogeneous; therefore, …

Zhen Xie

Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening

The use of combinatorial siRNAs shows great promise for drug discovery, but the identification of safe and effective siRNA combinations remains challenging. Here, we develop a …

Feng Guo

Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study

**Background**: Tertiary lymphoid structures (TLSs) exert a crucial role in the tumor microenvironment (TME), impacting tumor development, immune escape, and drug resistance. …

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Jia-Xin LEI