Journal Article

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

In the evolving landscape of cancer immunotherapy, tertiary lymphoid structures (TLS) have rapidly transitioned from a histological curiosity to a central mediator of anti-tumour …

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Chong-Xiang GAO

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning

Accurate risk stratification is crucial for determining the optimal treatment plan for patients with colorectal cancer (CRC). However, existing deep learning models perform poorly …

Jing Yang

Personalized risk stratification in colorectal cancer via PIANOS system

**Background**: Colorectal cancer (CRC) is the third-most common malignancy and the second-leading cause of cancer-related death worldwide. Despite considerable progress in …

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Du CAI

Certain pMMR colorectal cancer patients should undergo additional MSI-PCR testing to reduce the risk of misdiagnosing MSI-H and Lynch syndrome

This study analyzed colorectal cancers with proficient mismatch repair by immunohistochemistry but high microsatellite instability by PCR to characterize when discordance matters …

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Jing-Lin HUANG

Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics

Background: Young-onset colorectal cancer (CRC), affecting individuals <50 years of age, presents a significant health threat worldwide. The molecular and clinical characteristics …

Jia Ke

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer

Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion models based on artificial …

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Feng GAO

HADiff: hierarchy aggregated diffusion model for pathology image segmentation

The pathologists grade cancers by identifying the morphology of tumor areas, whereas this manual implementation is time-consuming and expensive. The most recent methods deploy …

Xuefeng Zhang

Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis

The rapid development of biological and medical examination methods has vastly expanded personal biomedical information, including molecular, cellular, image, and electronic health …

Junwei Liu

Liquid biopsy to identify Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma: the EMERALD multicentre study

**Background**: There is no clinically relevant serological marker for the early detection of oesophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's oesophagus (BE). …

Jinsei Miyoshi

SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation

The Transformer architecture has demonstrated remarkable results in 3D medical image segmentation due to its capability of modeling global relationships. However, it poses a …

Zhaohu Xing