Immunotherapy

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

This study established a multi-omics immune classification framework for colorectal cancer by integrating transcriptomic, mutational, and methylation features across large …

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Chu-Ling HU

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC

This study applies an integrative proteogenomic pipeline combining whole-genome sequencing, RNA-seq, and immunopeptidomics in colorectal cancer to systematically discover …

Haitao Xiang

The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target

In the evolving landscape of cancer immunotherapy, tertiary lymphoid structures (TLS) have rapidly transitioned from a histological curiosity to a central mediator of anti-tumour …

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Chong-Xiang GAO