Identification of a stemness-related gene signature for predicting prognosis of patients with adjuvant chemotherapy in colorectal cancer
**Background** Chemotherapy resistance is one of the major reasons for treatment failure and tumour recurrence in colorectal cancer. Recent studies indicate that cancer stem cells …
D. Cai
Integrating diffusion components of multi-omics datasets with application to cancer molecular subtyping
Cancer is a heterogeneous disease and consists of multiple molecular subtypes underlying the diverse clinical outcomes. Most strategies for cancer molecular subtyping are mainly …
Development of a novel liquid biopsy test to diagnose and locate gastrointestinal cancers
**Background**: Cancers of the gastrointestinal (GI) system, including esophagus, stomach, pancreas, gallbladder, liver, bile duct, colon, and rectum are estimated to account for …
Yuying Wang
Pathway analysis of hypoxia-related factors in early colorectal cancer patients with poor prognosis.
3613 **Background**: Colorectal cancer is one of the most common malignancies with a high mortality rate. Patients with stage I and stage II colorectal cancer have limited options …
Yingxin Tan
Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients
**Background**: Immune-related genes (IRGs) were found to be associated with the prognosis of colorectal cancer (CRC) patients. The aim of this study was to evaluate the impact of …
Jia Ke
Dysregulation of m6A RNA methylation regulators in colorectal cancer: Clinical implication as prognostic biomarkers and potential therapeutic targets
Purpose Among more than 100 known post-transcriptional modifications, N6-Methyladenosine (m6A) represents the most prevalent internal modification in mammalian mRNAs. This …
Raju Kandimalla
HTSanalyzeR2: An Ultra-Fast R/Bioconductor Package for High-Throughput Screens with Interactive Report
High-throughput screens (HTS) is one of the most promising tools in functional genomics and enables scientists to study genome-wide perturbations. Our previous work, HTSanalyzeR, …
