Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition

This study established a multi-omics immune classification framework for colorectal cancer by integrating transcriptomic, mutational, and methylation features across large discovery and validation cohorts. The authors identified three immune subtypes with distinct prognosis, tumor microenvironment states, and therapeutic implications, including an immune-cold subgroup marked by strong WNT pathway activation. Functional experiments further supported WNT-targeted inhibition as a strategy to enhance antitumor immunity and improve immunotherapy response in colorectal cancer.