Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Jan 21, 2026·

Chong Chen

1st Author

Du CAI

Co-1st Author

Xuanhui Liu

Co-1st Author

Yifan Zheng

Xinxin Huang

Dongwen Chen

Jiawei Cai

Yiran Bie

Zhengran Zhou

Chu-Ling HU

Zhengyu Wei

Kuntai Cai

Ting Li

Shuzhen Luo

Dongbing Liu

Kui Wu

Zerong Cai

Feng GAO

Xiaojian Wu

Co-Corresponding Author

Peishan Hu

Corresponding Author

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DOI

Abstract

This work investigates how the acidic tumor microenvironment drives colorectal cancer progression through protein lactylation. The authors show that lactylation decreases SLC26A3 stability and expression, weakens its interaction with HuR/CUGBP1, and promotes oncogenic mRNA regulation associated with recurrence, metastasis, and drug resistance. These findings position SLC26A3-related pathways as promising therapeutic and prognostic targets in colorectal carcinoma.

Type

Journal article

Publication

Cell Death & Disease