Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer

This study develops a radiogenomic framework to translate colorectal cancer molecular subtype information into clinically feasible prognostic biomarkers. Across 2948 patients from eight cohorts, the authors established both a subtype-associated gene signature and a non-invasive radiogenomic signature, each showing robust risk stratification performance. The work provides a cost-effective path for prognosis assessment and potential treatment guidance in routine clinical settings.