PIANOS
A normalization-free single-sample classifier for robust colorectal cancer risk stratification across platforms.
Overview
Current prognostic biomarkers for colorectal cancer often break down when cohorts, sequencing platforms, or preprocessing pipelines change. PIANOS addresses that translational bottleneck with a single-sample classifier that works on pathway rankings rather than fragile absolute measurements.
The system stratifies patients into clinically meaningful risk groups without cohort-wide normalization, making it much more suitable for real-world deployment. Beyond outcome prediction, PIANOS also reveals treatment-sensitive biological differences across subgroups, positioning the project as a bridge between transcriptomic modeling and actionable clinical decision support.
Validated across large international cohorts, PIANOS demonstrates that robust molecular stratification can be both technically rigorous and operationally practical.