International Journal of Surgery: TLS heterogeneity reveals prognosis and therapy opportunities in colorectal cancer
Sep 1, 2024
·
1 min read
Our team reported in International Journal of Surgery that tertiary lymphoid structure heterogeneity can define clinically meaningful colorectal cancer subgroups.
The study integrated multi-omics data, digital pathology, and clinicopathological information to characterize distinct TLS patterns and derive a quantitative TLSscore for patient stratification.
Key points:
- Identified three TLS patterns in colorectal cancer with distinct immune, stromal, and prognostic features.
- Developed a nine-gene TLSscore for individual-level risk and treatment stratification.
- Suggested lower TLSscore may align with immunotherapy benefit, while higher TLSscore may favor adjuvant chemotherapy.