Feng GAO

Associate Professor

Sun Yat-sen University

Dr. Feng GAO is currently an Associate Professor in the Department of Colorectal Surgery at the Sixth Affiliated Hospital, awarded by 100 Top Talents Program of Sun Yat-sen University. He was trained as a computer engineer initially and had his earliest career in finance. Thereafter, he pursed his PhD in the filed of cancer research by combining advanced artificial intelligence and big data technologies. Dr. GAO is a core member of the ICGC-ARGO CRC project. His major research interest is to develop artificial intelligence for diagnosis and prognosis in colorectal cancer.

Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics, 2015 - 2018
Visiting Student in Computer Science and Electronic Engineering, 2007 - 2008
BEng in Computer Science and Technology, 2005 - 2009

Publications

Segmentation Only Uses Sparse Annotations: Unified Weakly and Semi-Supervised Learning in Medical Images

Feng Gao*, Minhao Hu#, MinEr Zhong#, Shixiang Feng#, Xuwei Tian#, Xiaochun Meng#, Ma-yi-di-li Ni-jia-ti, Zeping Huang, Minyi Lv, Tao Song, Xiaofan Zhang*, Xiaoguang Zou*, Xiaojian Wu*

DOI Medical Image Analysis 2022

A Transcription Factor Signature Can Identify the CMS4 Subtype and Stratify the Prognostic Risk of Colorectal Cancer

Min-Er Zhong#, Ze-ping Huang#, Xin Wang#, Cai Du, Cheng-hang Li, Feng Gao*, Xiao-jian Wu*, Wei Wang*

DOI Frontiers in Oncology 2022

Multi-Size Deep Learning Based Preoperative Computed Tomography Signature for Prognosis Prediction of Colorectal Cancer

Cheng-hang Li#, Cai Du#, Min-Er Zhong#, Min-yi Lv, Ze-ping Huang, Qi-qi Zhu, Chu-ling Hu, Hao-ning Qi, Xiao-jian Wu*, Feng Gao*

DOI Frontiers in Genetics 2022

The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study

Qian Cai#, Yi-ze Mao#, Si-qi Dai#, Feng Gao#, Qian Xiao, Wan-ming Hu, Tao Qin, Qiu-xia Yang, Zhao-zhou Li, Du Cai, Min-Er Zhong, Ke-feng Ding*, Xiaojian Wu*, Rong Zhang*

DOI European Radiology 2022

Min-yi Lv#, Wei Wang#, Min-Er Zhong#, Cai Du, De-jun Fan, Cheng-hang Li, Wei-Bin Kou, Ze-ping Huang, Xin Duan, Chu-ling Hu, Qi-qi Zhu, Xiao-sheng He*, Feng Gao*

DOI Frontiers in Genetics 2022

Dissecting Cellular Heterogeneity Based on Network Denoising of scRNA-seq Using Local Scaling Self-Diffusion

Xin Duan#, Wei Wang, Feng Gao*, Xu-dong Lin*

DOI Frontiers in Genetics 2022

The enhanced cell cycle related to the response to adjuvant therapy in pancreatic ductal adenocarcinoma

Yi-ze Mao#, Wei-sheng Cheng#, Qiu-xia Yang#, Li-qin Li#, Wan-ming Hu, Ze-yu Shuang, De-jun Fan, Xin-lei Jiang, Feng Gao*, Sheng-ping Li*, Wei Wang*

PMID DOI Genomics 2022

Identification of an Autophagy-Related Gene Signature for the Prediction of Prognosis in Early-Stage Colorectal Cancer

Xu-tao Lin#, Qiu-ning Wu#, Si Qin#, De-jun Fan, Min-yi Lv, Xi Chen, Jia-wei Cai, Ze-rong Cai, Jing-rong Weng, Yi-feng Zou, Yu-ming Rong*, Feng Gao*

Link DOI Frontiers in Genetics 2021

Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis

Yu-feng Chen#, Zhao-liang Yu#, Min-yi Lv#, Ze-rong Cai, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*

PMID DOI Molecular Medicine 2021

Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients

Yu-feng Chen#, Zhao-liang Yu#, Min-yi Lv#, Bin Zheng, Ying-xin Tan, Jia Ke, Xuan-hui Liu, Ze-rong Cai, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*

DOI Frontiers in Medicine 2021

Predicting treatment response from longitudinal images using multi-task deep learning

Cheng Jin#, Heng Yu#, Jia Ke#, Peirong Ding#, Yongju Yi, Xiaofeng Jiang, Xin Duan, Jinghua Tang, Daniel T. Chang, Xiaojian Wu*, Feng Gao*, Ruijiang Li*

PMID DOI Nature Communications 2021

A novel cell-free DNA methylation-based model improves the early detection of colorectal cancer

Xianrui Wu#, Yunfeng Zhang#, Tuo Hu, Xiaowen He, Yifeng Zou, Qiling Deng, Jia Ke, Lei Lian, Xiaosheng He, Dezhi Zhao, Xuyu Cai, Zhiwei Chen, Xiaojian Wu, Jian‐Bing Fan*, Feng Gao*, Ping Lan*

PMID DOI Molecular Oncology 2021

Identification of prognostic spatial organization features in colorectal cancer microenvironment using deep learning on histopathology images

Lin Qi, Jia Ke, Zhaoliang Yu, Yi Cao, Yuni Lai, Yufeng Chen, Feng Gao*, Xin Wang*

DOI Medicine in Omics 2021

Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer

Zhao-Liang Yu#, Yu-Feng Chen#, Bin Zheng, Ze-Rong Cai, Yi-Feng Zou, Jia Ke, Ping Lan, Feng Gao*, Xiao-Jian Wu*

PMID DOI Cancer Cell International 2021

Du Cai#, Xin Duan#, Wei Wang#, Ze-Ping Huang, Qi-Qi Zhu, Min-Er Zhong, Min-Yi Lv, Cheng-Hang Li, Wei-Bin Kou, Xiao-Jian Wu*, Feng Gao*

PMID DOI Frontiers in Molecular Biosciences 2021

Jia Ke#, Xuan-hui Liu#, Xiao-feng Jiang, Zhen He, Jian Xiao, Bin Zheng, Yu-feng Chen, Ze-rong Cai, Xiao-bin Zheng, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*

DOI European Journal of Surgical Oncology 2020

Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers

Xiang Sun, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng Gao, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan

PMID DOI Nucleic Acids Research 2020

Integrating diffusion components of multi-omics datasets with application to cancer molecular subtyping

Xin Duan, Du Cai, Yufeng Chen, Qiqi Zhu, Zeping Huang, Chenghang Li, Xiaojian Wu, Feng Gao

Link Intelligent Systems for Molecular Biology 2020

Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor

Asif Rashid, Xin Duan, Feng Gao, Mengsu Yang*, Andrew Yen*

PMID DOI Cellular Signalling 2020

Development of a novel liquid biopsy test to diagnose and locate gastrointestinal cancers

Yuying Wang, Jianchao Zheng, Zhilong Li, Ruijingfang Jiang, Jiaxi Peng, Jianlong Sun, Guanghui Yang, Xin-Rong Yang, Ao Huang, Yupeng Wang, Yuan Jie, Xuanhui Liu, Feng Gao, Xiaojian Wu, Dansong Wang, Wenchuan Wu, Wenhui Lou, Jian Zhou, Jia Fan

Link DOI Journal of Clinical Oncology 2020

Automatic and Interpretable Model for Periodontitis Diagnosis in Panoramic Radiographs

Haoyang Li, Juexiao Zhou, Yi Zhou, Jieyu Chen, Feng Gao, Ying Xu, Xin Gao

Link Medical Image Computing and Computer Assisted Intervention 2020

Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer

Shu-Biao Ye#, Yi-Kan Cheng#, Jian-Cong Hu#, Feng Gao*, Ping Lan*

PMID DOI Annals of Translational Medicine 2020

Yangyang She, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jieyu Chen, Feng Gao*, Silian Fang*

PMID DOI Cancer cell International 2020

Multiomics-Based Colorectal Cancer Molecular Subtyping Using Local Scaling Network Fusion

Xin Duan, Kejun Wang, Jia Ke, Ping Lan, Feng Gao*, Xiaojian Wu*

PMID DOI Journal of Computational Biology 2019

A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients

Yi-Feng Zou, Yu-Ming Rong, Ying-Xin Tan, Jian Xiao, Zhao-Liang Yu, Yu-Feng Chen, Jia Ke, Cheng-Hang Li, Xi Chen, Xiao-Jian Wu, Ping Lan, Xu-Tao Lin*, Feng Gao*

PMID DOI Cancer Cell International 2019

Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms

Hui Chen#, Feng Gao#, Mian He#, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W.-H. Chan, Xin Wang*, Nathalie Wong*

PMID DOI Hepatology 2019

Liuyan Zhang#, Ping Zhu#, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang*, Feng Gao*, Peng Shu*

PMID DOI OncoTargets and Therapy 2019

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification

Feng Gao, Wei Wang, Miaomiao Tan, Lina Zhu, Yuchen Zhang, Evelyn Fessler, Louis Vermeulen*, Xin Wang*

PMID DOI Oncogenesis 2019

Bitao Jiang#, Qingsen Sun#, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang*, Feng Gao*, Peng Shu*

PMID DOI Medicine 2019

Gene Expression Signature in Surgical Tissues and Endoscopic Biopsies Identifies High-Risk T1 Colorectal Cancers

Raju Kandimalla#, Tsuyoshi Ozawa#, Feng Gao#, Xin Wang*, Ajay Goel*, T1 Colorectal Cancer Study Group

PMID DOI Gastroenterology 2019

Pathway analysis of hypoxia-related factors in early colorectal cancer patients with poor prognosis

Yingxin Tan, Yuming Rong, Zhaoliang Yu, Feng Gao, Yufeng Chen, Xutao Lin, Yifeng Zou, Xi Chen

Link Journal of Clinical Oncology 2019

Jia Ke, Xuanhui Liu, Xiaofeng Jiang, Yufeng Chen, Zerong Cai, Ping Lan, Xiaojian Wu, Feng Gao

Link Journal of Clinical Oncology 2019

RNAMethyPro: a biologically conserved signature of N6-methyladenosine regulators for predicting survival at pan-cancer level

Raju Kandimalla#, Feng Gao#, Ying Li#, Hao Huang, Jia Ke, Xin Deng, Linjie Zhao, Shengtao Zhou, Ajay Goel*, Xin Wang*

PMID DOI npj Precision Oncology 2019

Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma

Fuminori Sonohara#, Feng Gao#, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang*, Ajay Goel*

PMID DOI Annals of Surgery 2019

A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer

Daisuke Izumi#, Feng Gao#, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang*, Hideo Baba*, Ajay Goel*

PMID DOI EBioMedicine 2019

Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML

Rodica P. Bunaciu, Robert J. MacDonald, Holly A. Jensen, Feng Gao, Xin Wang, Lynn Johnson, Jeffrey D. Varner, Andrew Yen

PMID DOI Leukemia and Lymphoma 2018

High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients

Zhen Xu, Peilin Fang, Bingzhe Xu, Yufeng Lu, Jinghui Xiong, Feng Gao, Xin Wang, Jun Fan, Peng Shi

PMID DOI Nature Communications 2018

Dissecting cancer heterogeneity based on dimension reduction of transcriptomic profiles using extreme learning machines

Kejun Wang#, Xin Duan#, Feng Gao#, Wei Wang, Liangliang Liu, Xin Wang

PMID DOI PLoS ONE 2018

Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer

Raju Kandimalla#, Feng Gao#, Takatoshi Matsuyama, Toshiaki Ishikawa, Hiroyuki Uetake, Naoki Takahashi, Yasuhide Yamada, Carlos Becerra, Scott Kopetz, Xin Wang*, Ajay Goel*

PMID DOI Clinical Cancer Research 2018

A Novel Non-Invasive Circulating Mirna Signature for Detection of Esophageal Adenocarcinoma

Jinsei Miyoshi, Feng Gao, Shusuke Toden, Martha J. Shrubsole, Marco Scarpa, Timothy Whitsett, Landon Inge, Stephen J. Meltzer, Bottiglieri Teodoro, Helen G. Coleman, Lesley A. Anderson, Xin Wang, Ajay Goel

Link Gastroenterology 2018

Dysregulation of m6A RNA methylation regulators in colorectal cancer: Clinical implication as prognostic biomarkers and potential therapeutic targets

Raju Kandimalla, Feng Gao, Chun Ruan, Michael Hsieh, Xin Wang, Ajay Goel

Link Cancer Research 2018

A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes

Tsuyoshi Ozawa#, Raju Kandimalla#, Feng Gao#, Hiroaki Nozawa, Keisuke Hata, Hiroshi Nagata, Satoshi Okada, Daisuke Izumi, Hideo Baba, James Fleshman, Xin Wang, Toshiaki Watanabe, Ajay Goel

PMID DOI Gastroenterology 2018

Poor-prognosis nasopharyngeal carcinoma as defined by a molecularly distinct subgroup and prediction by a miRNA expression signature

Lan Zhao, Feng Gao, Wei Wang, Xin Duan, Yuchen Zhang, Lina Zhu, Xin Wang

Link Journal of Clinical Oncology 2017

Identification, Development and Validation of a Circulating Mirna-Based Diagnostic Signature for Early Detection of Gastric Cancer

Daisuke Izumi, Shusuke Toden, Feng Gao, Jacob Turner, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba, Ajay Goel

Link Gastroenterology 2017

A Novel Mirna Signature for the Detection of Lymph Node Metastasis in Submucosal Colorectal Cancer Patients

Tsuyoshi Ozawa, Feng Gao, Hiroaki Nozawa, Keisuke Hata, Hiroshi Nagata, Daisuke Izumi, Hideo Baba, Xin Wang, Toshiaki Watanabe, Ajay Goel

Link Gastroenterology 2017

A Novel Mirna-Based, Non-Invasive, Diagnostic Panel for Detection of Esophageal Squamous Cell Carcinoma

Jinsei Miyoshi, Shusuke Toden, Jacob Turner, Feng Gao, Raju Kandimalla, Xin Wang, Mitsuro Kanda, Hideo Baba, Yasuhiro Kodera, Ajay Goel

Link Gastroenterology 2017

Genome-Wide Analysis Revealed a Robust Gene Expression Signature to Identify Lymph Node Metastasis in Submucosal Colorectal Cancer

Raju Kandimalla, Tsuyoshi Ozawa, Feng Gao, Keisuke Hata, Hiroaki Nozawa, Hiroshi Nagata, Daisuke Izumi, Hideo Baba, James W Fleshman, Xin Wang, Toshiaki Watanabe, Ajay Goel

Link Gastroenterology 2017

Genome-wide discovery and identification of a novel microrna signature for recurrence prediction in colorectal cancer

Raju Kandimalla, Feng Gao, Naoki Takahashi, Yasuhide Yamada, Takatoshi Matsuyama, Toshiyaki Ishikawa, Xin Wang, Ajay Goel

Link Cancer Research 2017