Feng GAO

Feng GAO

Associate Professor

Sun Yat-sen University



Dr. Feng Gao is currently an Associate Professor in the Department of Colorectal Surgery at the Sixth Affiliated Hospital, supported by Sun Yat-sen University’s prestigious 100 Top Talents Program. Initially trained as a computer engineer, Dr. Gao briefly worked in engineering before transitioning to a role in finance. He later pursued a Ph.D. in cancer research, focusing on the integration of advanced artificial intelligence and big data technologies. As a core member of the ICGC-ARGO CRC project, his primary research interest lies in developing AI-driven solutions for the diagnosis and prognosis of colorectal cancer. He is also keenly interested in applying cutting-edge technologies to other medical fields, including diabetes, reproductive health, pediatrics, and dentistry.

Interests

  • Artificial Intelligence
  • Colorectal Cancer

Education

  • Joint PhD in Cancer Biology and Bioinformatics, 2015 - 2018

    City University of Hong Kong & Cornell University

  • Visiting Student in Computer Science and Electronic Engineering, 2007 - 2008

    Kumamoto University

  • BEng in Computer Science and Technology, 2005 - 2009

    Shandong University

Publications

Deciphering tertiary lymphoid structure heterogeneity reveals prognostic signature and therapeutic potentials for colorectal cancer: a multicenter retrospective cohort study
Jia-Xin Lei#, Runxian Wang#, Chuling Hu, Xiaoying Lou, Min-Yi Lv, Chenghang Li, Baowen Gai, Xiao-Jian Wu*, Ruoxu Dou*, Du Cai*, Feng Gao*
PMID DOI International Journal of Surgery  2024
TMO-Net: an explainable pretrained multi-omics model for multi-task learning in oncology
Feng-Ao Wang#, Zhenfeng Zhuang#, Feng Gao#, Ruikun He, Shaoting Zhang, Liansheng Wang*, Junwei Liu*, Yixue Li*
PMID DOI Genome Biology  2024
Cross-Level Contrastive Learning and Consistency Constraint for Semi-Supervised Medical Image Segmentation
Xinkai Zhao, Chaowei Fang, De-Jun Fan, Xutao Lin, Feng Gao, Guanbin Li
DOI IEEE International Symposium on Biomedical Imaging  2024
Structure Embedded Nucleus Classification for Histopathology Images
Wei Lou, Xiang Wan, Guanbin Li, Xiaoying Lou, Chenghang Li, Feng Gao, Haofeng Li
PMID DOI IEEE Transactions on Medical Imaging  2024
Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
Ngan Pan Bennett Au, Tan Wu, Xinyu Chen, Feng Gao, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H Geschwind, Giovanni Coppola, Xin Wang, Chi Him Eddie Ma
PMID DOI Neuron  2023
Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies
Min‐Yi Lv#, Du Cai#, Cheng‐Hang Li#, Junguo Chen#, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan*, Xiaojian Wu*, Xiaosheng He*, Feng Gao*
PMID DOI MedComm  2023
Segmentation Only Uses Sparse Annotations: Unified Weakly and Semi-Supervised Learning in Medical Images
Feng Gao*, Minhao Hu#, MinEr Zhong#, Shixiang Feng#, Xuwei Tian#, Xiaochun Meng#, Ma-yi-di-li Ni-jia-ti, Zeping Huang, Minyi Lv, Tao Song, Xiaofan Zhang*, Xiaoguang Zou*, Xiaojian Wu*
DOI Medical Image Analysis  2022
A Transcription Factor Signature Can Identify the CMS4 Subtype and Stratify the Prognostic Risk of Colorectal Cancer
Min-Er Zhong#, Ze-ping Huang#, Xin Wang#, Cai Du, Cheng-hang Li, Feng Gao*, Xiao-jian Wu*, Wei Wang*
DOI Frontiers in Oncology  2022
Multi-Size Deep Learning Based Preoperative Computed Tomography Signature for Prognosis Prediction of Colorectal Cancer
Cheng-hang Li#, Cai Du#, Min-Er Zhong#, Min-yi Lv, Ze-ping Huang, Qi-qi Zhu, Chu-ling Hu, Hao-ning Qi, Xiao-jian Wu*, Feng Gao*
DOI Frontiers in Genetics  2022
The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study
Qian Cai#, Yi-ze Mao#, Si-qi Dai#, Feng Gao#, Qian Xiao, Wan-ming Hu, Tao Qin, Qiu-xia Yang, Zhao-zhou Li, Du Cai, Min-Er Zhong, Ke-feng Ding*, Xiaojian Wu*, Rong Zhang*
DOI European Radiology  2022
DNA Repair–Related Gene Signature in Predicting Prognosis of Colorectal Cancer Patients
Min-yi Lv#, Wei Wang#, Min-Er Zhong#, Cai Du, De-jun Fan, Cheng-hang Li, Wei-Bin Kou, Ze-ping Huang, Xin Duan, Chu-ling Hu, Qi-qi Zhu, Xiao-sheng He*, Feng Gao*
DOI Frontiers in Genetics  2022
A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
Jinsei Miyoshi*, Zhongxu Zhu*, Aiping Luo*, Shusuke Toden*, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal M. Parker, Minjie Wang, Feng Gao, Ali H. Zaidi, Hideo Baba, Yasuhiro Kodera, Yongping Cui, Xin Wang#, Zhihua Liu#, Ajay Goel#
PMID DOI Molecular Cancer  2022
Dissecting Cellular Heterogeneity Based on Network Denoising of scRNA-seq Using Local Scaling Self-Diffusion
Xin Duan#, Wei Wang, Feng Gao*, Xu-dong Lin*
DOI Frontiers in Genetics  2022
The enhanced cell cycle related to the response to adjuvant therapy in pancreatic ductal adenocarcinoma
Yi-ze Mao#, Wei-sheng Cheng#, Qiu-xia Yang#, Li-qin Li#, Wan-ming Hu, Ze-yu Shuang, De-jun Fan, Xin-lei Jiang, Feng Gao*, Sheng-ping Li*, Wei Wang*
PMID DOI Genomics  2022
Identification of an Autophagy-Related Gene Signature for the Prediction of Prognosis in Early-Stage Colorectal Cancer
Xu-tao Lin#, Qiu-ning Wu#, Si Qin#, De-jun Fan, Min-yi Lv, Xi Chen, Jia-wei Cai, Ze-rong Cai, Jing-rong Weng, Yi-feng Zou, Yu-ming Rong*, Feng Gao*
Link DOI Frontiers in Genetics  2021
Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis
Yu-feng Chen#, Zhao-liang Yu#, Min-yi Lv#, Ze-rong Cai, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*
PMID DOI Molecular Medicine  2021
Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients
Yu-feng Chen#, Zhao-liang Yu#, Min-yi Lv#, Bin Zheng, Ying-xin Tan, Jia Ke, Xuan-hui Liu, Ze-rong Cai, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*
DOI Frontiers in Medicine  2021
Predicting treatment response from longitudinal images using multi-task deep learning
Cheng Jin#, Heng Yu#, Jia Ke#, Peirong Ding#, Yongju Yi, Xiaofeng Jiang, Xin Duan, Jinghua Tang, Daniel T. Chang, Xiaojian Wu*, Feng Gao*, Ruijiang Li*
PMID DOI Nature Communications  2021
A novel cell-free DNA methylation-based model improves the early detection of colorectal cancer
Xianrui Wu#, Yunfeng Zhang#, Tuo Hu, Xiaowen He, Yifeng Zou, Qiling Deng, Jia Ke, Lei Lian, Xiaosheng He, Dezhi Zhao, Xuyu Cai, Zhiwei Chen, Xiaojian Wu, Jian‐Bing Fan*, Feng Gao*, Ping Lan*
PMID DOI Molecular Oncology  2021
Identification of prognostic spatial organization features in colorectal cancer microenvironment using deep learning on histopathology images
Lin Qi, Jia Ke, Zhaoliang Yu, Yi Cao, Yuni Lai, Yufeng Chen, Feng Gao*, Xin Wang*
DOI Medicine in Omics  2021
Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer
Zhao-Liang Yu#, Yu-Feng Chen#, Bin Zheng, Ze-Rong Cai, Yi-Feng Zou, Jia Ke, Ping Lan, Feng Gao*, Xiao-Jian Wu*
PMID DOI Cancer Cell International  2021
A Metabolism-Related Radiomics Signature for Predicting the Prognosis of Colorectal Cancer
Du Cai#, Xin Duan#, Wei Wang#, Ze-Ping Huang, Qi-Qi Zhu, Min-Er Zhong, Min-Yi Lv, Cheng-Hang Li, Wei-Bin Kou, Xiao-Jian Wu*, Feng Gao*
PMID DOI Frontiers in Molecular Biosciences  2021
Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients
Jia Ke#, Xuan-hui Liu#, Xiao-feng Jiang, Zhen He, Jian Xiao, Bin Zheng, Yu-feng Chen, Ze-rong Cai, Xiao-bin Zheng, Yi-feng Zou, Ping Lan*, Xiao-jian Wu*, Feng Gao*
DOI European Journal of Surgical Oncology  2020
Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers
Xiang Sun, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng Gao, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan
PMID DOI Nucleic Acids Research  2020
Integrating diffusion components of multi-omics datasets with application to cancer molecular subtyping
Xin Duan, Du Cai, Yufeng Chen, Qiqi Zhu, Zeping Huang, Chenghang Li, Xiaojian Wu, Feng Gao
Link Intelligent Systems for Molecular Biology  2020
Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor
Asif Rashid, Xin Duan, Feng Gao, Mengsu Yang*, Andrew Yen*
PMID DOI Cellular Signalling  2020
Development of a novel liquid biopsy test to diagnose and locate gastrointestinal cancers
Yuying Wang, Jianchao Zheng, Zhilong Li, Ruijingfang Jiang, Jiaxi Peng, Jianlong Sun, Guanghui Yang, Xin-Rong Yang, Ao Huang, Yupeng Wang, Yuan Jie, Xuanhui Liu, Feng Gao, Xiaojian Wu, Dansong Wang, Wenchuan Wu, Wenhui Lou, Jian Zhou, Jia Fan
Link DOI Journal of Clinical Oncology  2020
Automatic and Interpretable Model for Periodontitis Diagnosis in Panoramic Radiographs
Haoyang Li, Juexiao Zhou, Yi Zhou, Jieyu Chen, Feng Gao, Ying Xu, Xin Gao
Link Medical Image Computing and Computer Assisted Intervention  2020
Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer
Shu-Biao Ye#, Yi-Kan Cheng#, Jian-Cong Hu#, Feng Gao*, Ping Lan*
PMID DOI Annals of Translational Medicine  2020
Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma
Yangyang She, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jieyu Chen, Feng Gao*, Silian Fang*
PMID DOI Cancer cell International  2020
Multiomics-Based Colorectal Cancer Molecular Subtyping Using Local Scaling Network Fusion
Xin Duan, Kejun Wang, Jia Ke, Ping Lan, Feng Gao*, Xiaojian Wu*
PMID DOI Journal of Computational Biology  2019
A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients
Yi-Feng Zou, Yu-Ming Rong, Ying-Xin Tan, Jian Xiao, Zhao-Liang Yu, Yu-Feng Chen, Jia Ke, Cheng-Hang Li, Xi Chen, Xiao-Jian Wu, Ping Lan, Xu-Tao Lin*, Feng Gao*
PMID DOI Cancer Cell International  2019
Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms
Hui Chen#, Feng Gao#, Mian He#, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W.-H. Chan, Xin Wang*, Nathalie Wong*
PMID DOI Hepatology  2019
An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma
Liuyan Zhang#, Ping Zhu#, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang*, Feng Gao*, Peng Shu*
PMID DOI OncoTargets and Therapy  2019
DeepCC: a novel deep learning-based framework for cancer molecular subtype classification
Feng Gao, Wei Wang, Miaomiao Tan, Lina Zhu, Yuchen Zhang, Evelyn Fessler, Louis Vermeulen*, Xin Wang*
PMID DOI Oncogenesis  2019
An immune-related gene signature predicts prognosis of gastric cancer
Bitao Jiang#, Qingsen Sun#, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang*, Feng Gao*, Peng Shu*
PMID DOI Medicine  2019
Gene Expression Signature in Surgical Tissues and Endoscopic Biopsies Identifies High-Risk T1 Colorectal Cancers
Raju Kandimalla#, Tsuyoshi Ozawa#, Feng Gao#, Xin Wang*, Ajay Goel*, T1 Colorectal Cancer Study Group
PMID DOI Gastroenterology  2019
Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients
Jia Ke, Xuanhui Liu, Xiaofeng Jiang, Yufeng Chen, Zerong Cai, Ping Lan, Xiaojian Wu, Feng Gao
Link Journal of Clinical Oncology  2019
Pathway analysis of hypoxia-related factors in early colorectal cancer patients with poor prognosis
Yingxin Tan, Yuming Rong, Zhaoliang Yu, Feng Gao, Yufeng Chen, Xutao Lin, Yifeng Zou, Xi Chen
Link Journal of Clinical Oncology  2019
RNAMethyPro: a biologically conserved signature of N6-methyladenosine regulators for predicting survival at pan-cancer level
Raju Kandimalla#, Feng Gao#, Ying Li#, Hao Huang, Jia Ke, Xin Deng, Linjie Zhao, Shengtao Zhou, Ajay Goel*, Xin Wang*
PMID DOI npj Precision Oncology  2019
Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma
Fuminori Sonohara#, Feng Gao#, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang*, Ajay Goel*
PMID DOI Annals of Surgery  2019
A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer
Daisuke Izumi#, Feng Gao#, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang*, Hideo Baba*, Ajay Goel*
PMID DOI EBioMedicine  2019
Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML
Rodica P. Bunaciu, Robert J. MacDonald, Holly A. Jensen, Feng Gao, Xin Wang, Lynn Johnson, Jeffrey D. Varner, Andrew Yen
PMID DOI Leukemia and Lymphoma  2018
High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients
Zhen Xu, Peilin Fang, Bingzhe Xu, Yufeng Lu, Jinghui Xiong, Feng Gao, Xin Wang, Jun Fan, Peng Shi
PMID DOI Nature Communications  2018
Dissecting cancer heterogeneity based on dimension reduction of transcriptomic profiles using extreme learning machines
Kejun Wang#, Xin Duan#, Feng Gao#, Wei Wang, Liangliang Liu, Xin Wang
PMID DOI PLoS ONE  2018
Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer
Raju Kandimalla#, Feng Gao#, Takatoshi Matsuyama, Toshiaki Ishikawa, Hiroyuki Uetake, Naoki Takahashi, Yasuhide Yamada, Carlos Becerra, Scott Kopetz, Xin Wang*, Ajay Goel*
PMID DOI Clinical Cancer Research  2018
A Novel Non-Invasive Circulating Mirna Signature for Detection of Esophageal Adenocarcinoma
Jinsei Miyoshi, Feng Gao, Shusuke Toden, Martha J. Shrubsole, Marco Scarpa, Timothy Whitsett, Landon Inge, Stephen J. Meltzer, Bottiglieri Teodoro, Helen G. Coleman, Lesley A. Anderson, Xin Wang, Ajay Goel
Link Gastroenterology  2018
Dysregulation of m6A RNA methylation regulators in colorectal cancer: Clinical implication as prognostic biomarkers and potential therapeutic targets
Raju Kandimalla, Feng Gao, Chun Ruan, Michael Hsieh, Xin Wang, Ajay Goel
Link Cancer Research  2018
A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes
Tsuyoshi Ozawa#, Raju Kandimalla#, Feng Gao#, Hiroaki Nozawa, Keisuke Hata, Hiroshi Nagata, Satoshi Okada, Daisuke Izumi, Hideo Baba, James Fleshman, Xin Wang, Toshiaki Watanabe, Ajay Goel
PMID DOI Gastroenterology  2018
Poor-prognosis nasopharyngeal carcinoma as defined by a molecularly distinct subgroup and prediction by a miRNA expression signature
Lan Zhao, Feng Gao, Wei Wang, Xin Duan, Yuchen Zhang, Lina Zhu, Xin Wang
Link Journal of Clinical Oncology  2017
Identification, Development and Validation of a Circulating Mirna-Based Diagnostic Signature for Early Detection of Gastric Cancer
Daisuke Izumi, Shusuke Toden, Feng Gao, Jacob Turner, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba, Ajay Goel
Link Gastroenterology  2017
A Novel Mirna Signature for the Detection of Lymph Node Metastasis in Submucosal Colorectal Cancer Patients
Tsuyoshi Ozawa, Feng Gao, Hiroaki Nozawa, Keisuke Hata, Hiroshi Nagata, Daisuke Izumi, Hideo Baba, Xin Wang, Toshiaki Watanabe, Ajay Goel
Link Gastroenterology  2017
A Novel Mirna-Based, Non-Invasive, Diagnostic Panel for Detection of Esophageal Squamous Cell Carcinoma
Jinsei Miyoshi, Shusuke Toden, Jacob Turner, Feng Gao, Raju Kandimalla, Xin Wang, Mitsuro Kanda, Hideo Baba, Yasuhiro Kodera, Ajay Goel
Link Gastroenterology  2017
Genome-Wide Analysis Revealed a Robust Gene Expression Signature to Identify Lymph Node Metastasis in Submucosal Colorectal Cancer
Raju Kandimalla, Tsuyoshi Ozawa, Feng Gao, Keisuke Hata, Hiroaki Nozawa, Hiroshi Nagata, Daisuke Izumi, Hideo Baba, James W Fleshman, Xin Wang, Toshiaki Watanabe, Ajay Goel
Link Gastroenterology  2017
Genome-wide discovery and identification of a novel microrna signature for recurrence prediction in colorectal cancer
Raju Kandimalla, Feng Gao, Naoki Takahashi, Yasuhide Yamada, Takatoshi Matsuyama, Toshiyaki Ishikawa, Xin Wang, Ajay Goel
Link Cancer Research  2017