Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and the data analysis lead for the ICGC-ARGO Colorectal Cancer project. Leveraging his interdisciplinary expertise in computer science and oncology, Dr. Gao’s lab is dedicated to building the critical technical infrastructure for the “AI-Native Future Hospital.” By pioneering “AI Doctor 3.0” through multi-agent systems, multimodal foundation models, and intelligent surgical computing, his team is driving the paradigm shift from passive medical tools to autonomous, collaborative clinical intelligence. Using colorectal cancer as a flagship testing ground, Dr. Gao focuses on architecture-driven AI paradigms—rather than mere parameter scaling—to create full-stack, scalable solutions that fundamentally restructure healthcare supply and delivery.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics
City University of Hong Kong & Cornell University
2015 - 2018
Visiting Student in Computer Science and Electronic Engineering
Kumamoto University
2007 - 2008
BEng in Computer Science and Technology
Shandong University
2005 - 2009

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Xin DUAN^†, Du CAI, Yufeng Chen, Qi-Qi ZHU, Ze-Ping HUANG, Cheng-Hang LI, Xiaojian Wu, Feng GAO^* (2020). Conference Paper Integrating diffusion components of multi-omics datasets with application to cancer molecular subtyping. Intelligent Systems for Molecular Biology.

Asif Rashid^†, Xin DUAN^†, Feng GAO^†, Mengsu Yang^*, Andrew Yen^* (2020). Journal Article Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Cellular Signalling.

Yuying Wang^†, Jianchao Zheng, Zhilong Li, Ruijingfang Jiang, Jiaxi Peng, Jianlong Sun, Guanghui Yang, Xin-Rong Yang, Ao Huang, Yupeng Wang, Yuan Jie, Xuanhui Liu, Feng GAO, Xiaojian Wu, Dansong Wang, Wenchuan Wu, Wenhui Lou, Jian Zhou, Jia Fan^* (2020). Conference Paper Development of a novel liquid biopsy test to diagnose and locate gastrointestinal cancers. Journal of Clinical Oncology.

Asif Rashid^†, Xin DUAN^†, Feng GAO^†, Mengsu Yang, Andrew Yen^* (2020). Journal Article Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation. Oncotarget.

Shu-Biao Ye^†, Yi-Kan Cheng^†, Jian-Cong Hu^†, Feng GAO^*, Ping Lan^* (2020). Journal Article Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer. Annals of Translational Medicine.

Yangyang She^†, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jie-Yu CHEN, Feng GAO^*, Silian Fang^* (2020). Journal Article Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma. Cancer Cell International.

Xin DUAN^†, Kejun Wang, Jia Ke, Ping Lan, Feng GAO^*, Xiaojian Wu^* (2019). Journal Article Multiomics-Based Colorectal Cancer Molecular Subtyping Using Local Scaling Network Fusion. Journal of Computational Biology.

Daisuke Izumi^†, Feng GAO, Yuetong Chen, Takatsugu Ishimoto, Kei Horino, Shu Shimada, Yasuhiro Kodera, Hideo Baba, Jinfei Chen, Xin Wang, Ajay Goel^* (2019). Conference Paper Identification, development and validation of a circulating miRNA-based diagnostic signature for early detection of gastric cancer. Annals of Oncology.

Yi-Feng Zou^†, Yu-Ming Rong^†, Ying-Xin Tan^†, Jian Xiao, Zhao-Liang Yu, Yu-Feng Chen, Jia Ke, Cheng-Hang LI, Xi Chen, Xiao-Jian Wu, Ping Lan, Xu-Tao Lin, Feng GAO^* (2019). Journal Article A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients. Cancer Cell International.

Hui Chen^†, Feng GAO^†, Mian He^†, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W.-H. Chan, Xin Wang^*, Nathalie Wong^* (2019). Journal Article Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms. Hepatology.

Liuyan Zhang^†, Ping Zhu^†, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang^*, Feng GAO^*, Peng Shu^* (2019). Journal Article An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma. OncoTargets and Therapy.

Feng GAO^†, Wei Wang, Miaomiao Tan, Lina Zhu, Yuchen Zhang, Evelyn Fessler, Louis Vermeulen, Xin Wang^* (2019). Journal Article DeepCC: a novel deep learning-based framework for cancer molecular subtype classification. Oncogenesis.

Bitao Jiang^†, Qingsen Sun^†, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang^*, Feng GAO^*, Peng Shu^* (2019). Journal Article An immune-related gene signature predicts prognosis of gastric cancer. Medicine.

Raju Kandimalla^†, Tsuyoshi Ozawa^†, Feng GAO^†, Xin Wang^*, Ajay Goel^*, T1 Colorectal Cancer Study Group (2019). Journal Article Gene expression signature in surgical tissues and endoscopic biopsies identifies high-risk T1 colorectal cancers. Gastroenterology.

Yingxin Tan^†, Yuming Rong, Zhaoliang Yu, Feng GAO, Yufeng Chen, Xutao Lin, Yifeng Zou, Xi Chen^* (2019). Conference Paper Pathway analysis of hypoxia-related factors in early colorectal cancer patients with poor prognosis.. Journal of Clinical Oncology.

Jia Ke^†, Xuanhui Liu, Xiaofeng Jiang, Yufeng Chen, Zerong Cai, Ping Lan, Xiaojian Wu, Feng GAO^* (2019). Conference Paper Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients. Journal of Clinical Oncology.

Raju Kandimalla^†, Feng GAO^†, Ying Li^†, Hao Huang, Jia Ke, Xin Deng, Linjie Zhao, Shengtao Zhou, Ajay Goel^*, Xin Wang^* (2019). Journal Article RNAMethyPro: a biologically conserved signature of N6-methyladenosine regulators for predicting survival at pan-cancer level. npj Precision Oncology.

Fuminori Sonohara^†, Feng GAO^†, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang^*, Ajay Goel^* (2019). Journal Article Genome-wide discovery of a novel gene-expression signature for the identification of lymph node metastasis in esophageal squamous cell carcinoma. Annals of Surgery.

Wei Wang^†, Raju Kandimalla^†, Hao Huang^†, Lina Zhu, Ying Li, Feng GAO, Ajay Goel, Xin Wang^* (2019). Journal Article Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities. Seminars in Cancer Biology.

Daisuke Izumi^†, Feng GAO^†, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba^*, Ajay Goel^* (2019). Journal Article A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer. EBioMedicine.