Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and the data analysis lead for the ICGC-ARGO Colorectal Cancer project. Leveraging his interdisciplinary expertise in computer science and oncology, Dr. Gao’s lab is dedicated to building the critical technical infrastructure for the “AI-Native Future Hospital.” By pioneering “AI Doctor 3.0” through multi-agent systems, multimodal foundation models, and intelligent surgical computing, his team is driving the paradigm shift from passive medical tools to autonomous, collaborative clinical intelligence. Using colorectal cancer as a flagship testing ground, Dr. Gao focuses on architecture-driven AI paradigms—rather than mere parameter scaling—to create full-stack, scalable solutions that fundamentally restructure healthcare supply and delivery.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics
City University of Hong Kong & Cornell University
2015 - 2018
Visiting Student in Computer Science and Electronic Engineering
Kumamoto University
2007 - 2008
BEng in Computer Science and Technology
Shandong University
2005 - 2009

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Yu-Feng Chen^†, Zhao-Liang Yu, Min-Yi LV, Bin Zheng, Ying-Xin Tan, Jia Ke, Xuan-Hui Liu, Ze-Rong Cai, Yi-Feng Zou, Ping Lan^*, Xiao-Jian Wu^*, Feng GAO^* (2021). Journal Article Genome-Wide analysis reveals hypoxic microenvironment is associated with immunosuppression in poor survival of stage II/III colorectal cancer patients. Frontiers in Medicine.

Xuanhui Liu^†, Yani Zhang, Xiurui Zhu, Sheeno P. Thyparambil, Wei-Li Liao, Xiao-Bin Zheng, Jin You, Ashiq Masood, Zhen Li, Gabriel Yang, Xiaoming Yao, Shiying Hao, Robert Heaton, James Schilling, Karl G. Sylvester, Jiayu Liao, Feng GAO, Ping Lan, Xuefeng Ling, Xiaojian Wu^* (2021). Conference Paper Multi-omics longitudinal analyses in stages I to III CRC patients: Surveillance liquid biopsy test to predict early recurrence and enable risk-stratified postoperative CRC management.. Journal of Clinical Oncology.

Xiaying Kuang^†, Du CAI, Ying Lin, Feng GAO^* (2021). Conference Paper Integrated immune-related gene signature to predict clinical outcome for patients with luminal B breast cancer.. Journal of Clinical Oncology.

Qi-Qi ZHU^†, Du CAI, Wei Wang, Min-Er ZHONG, De-Jun FAN, Xuanhui Liu, Cheng-Hang LI, Ze-Ping HUANG, Min-Yi LV, Chu-Ling HU, Xin DUAN, Xiaojian Wu, Feng GAO^* (2021). Conference Paper Identifying an immune-related gene-pair for prognosis prediction of metastatic colorectal cancer.. Journal of Clinical Oncology.

Yu-Feng Chen^†, Xiaojian Wu, Feng GAO^* (2021). Conference Paper Genome-wide analysis indicating cancer associated fibroblast (CAF) impacts on colorectal cancer (CRC) prognosis via immunosuppression.. Journal of Clinical Oncology.

Du CAI^†, Wei Wang, Min-Er ZHONG, De-Jun FAN, Xuanhui Liu, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Min-Yi LV, Chu-Ling HU, Xin DUAN, Xiaojian Wu, Feng GAO^* (2021). Conference Paper Deep learning to identify a gene signature associated with molecular subtypes that predicts prognosis in colorectal cancer.. Journal of Clinical Oncology.

Min-Er ZHONG^†, Du CAI, De-Jun FAN, Wei Wang, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Min-Yi LV, Chu-Ling HU, Xiaojian Wu, Feng GAO^* (2021). Conference Paper A model combing an immune-related genes signature and an extracellular matrix-related genes signature in predicting prognosis of left-and right-sided colon cancer. Journal of Clinical Oncology.

Xiaobin Zheng^†, Xuanhui Liu, Xiaoli Zhong, Ping Lan, Feng GAO, Jia Ke, Xiao-Jian Wu^* (2021). Conference Paper Su029 INTEGRATING PROGNOSIS-RELATED GENES WITH IMMUNE-RELATED GENE SIGNATURE FOR SURVIVAL STRATIFICATION OF EARLY-STAGE COLORECTAL CANCER. Gastroenterology.

Xinkai Zhao^†, Chaowei Fang, Feng GAO, FAN De-Jun, Xutao Lin, Guanbin Li^* (2021). Conference Paper Deep transformers for fast small intestine grounding in capsule endoscope video. IEEE International Symposium on Biomedical Imaging.

Cheng Jin^†, Heng Yu^†, Jia Ke^†, Peirong Ding^†, Yongju Yi, Xiaofeng Jiang, Xin DUAN, Jinghua Tang, Daniel T. Chang, Xiaojian Wu^*, Feng GAO^*, Ruijiang Li^* (2021). Journal Article Predicting treatment response from longitudinal images using multi-task deep learning. Nature Communications.

Xianrui Wu^†, Yunfeng Zhang^†, Tuo Hu, Xiaowen He, Yifeng Zou, Qiling Deng, Jia Ke, Lei Lian, Xiaosheng He, Dezhi Zhao, Xuyu Cai, Zhiwei Chen, Xiaojian Wu, Jian-Bing Fan^*, Feng GAO^*, Ping Lan^* (2021). Journal Article A novel cell-free DNA methylation-based model improves the early detection of colorectal cancer. Molecular Oncology.

Lin Qi^†, Jia Ke, Zhaoliang Yu, Yi Cao, Yuni Lai, Yufeng Chen, Feng GAO^*, Xin Wang^* (2021). Journal Article Identification of prognostic spatial organization features in colorectal cancer microenvironment using deep learning on histopathology images. Medicine in Omics.

Zhao-Liang Yu^†, Yu-Feng Chen^†, Bin Zheng, Ze-Rong Cai, Yi-Feng Zou, Jia Ke, Ping Lan, Feng GAO^*, Xiao-Jian Wu^* (2021). Journal Article Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer. Cancer Cell International.

Du CAI^†, Xin DUAN^†, Wei Wang, Ze-Ping HUANG, Qi-Qi ZHU, Min-Er ZHONG, Min-Yi LV, Cheng-Hang LI, Wei-Bin KOU, Xiao-Jian Wu^*, Feng GAO^* (2021). Journal Article A metabolism-related radiomics signature for predicting the prognosis of colorectal cancer. Frontiers in Molecular Biosciences.

Zhongxu Zhu^†, Guiyuan Han, Hao Huang, Lingli He, Yu Chen, Jia Ke, Feng GAO, Louis Vermeulen, Xin Wang^* (2020). Book Chapter Genome-wide Discovery of MicroRNA Biomarkers for Cancer Precision Medicine. Detection Methods in Precision Medicine.

Haoyang Li^†, Juexiao Zhou, Yi Zhou, Jie-Yu CHEN, Feng GAO, Ying Xu, Xin Gao^* (2020). Conference Paper Automatic and interpretable model for periodontitis diagnosis in panoramic radiographs. Medical Image Computing and Computer Assisted Intervention.

D. Cai^†, Y. Che, Z. Yu, C. Li, X. Duan, J. Ke, X. Wu, Feng GAO^* (2020). Conference Paper Identification of a stemness-related gene signature for predicting prognosis of patients with adjuvant chemotherapy in colorectal cancer. Annals of Oncology.

Jia Ke^†, Xuan-Hui Liu^†, Xiao-Feng Jiang, Zhen He, Jian Xiao, Bin Zheng, Yu-Feng Chen, Ze-Rong Cai, Xiao-Bin Zheng, Yi-Feng Zou, Ping Lan, Xiao-Jian Wu^*, Feng GAO^* (2020). Journal Article Immune-related gene signature in predicting prognosis of early-stage colorectal cancer patients. European Journal of Surgical Oncology.

Xin DUAN^†, Kejun Wang, Jia Ke, Ping Lan, Feng GAO^*, Xiaojian Wu^* (2020). Journal Article Multiomics-based colorectal cancer molecular subtyping using local scaling network fusion. Journal of Computational Biology.

Xiang Sun^†, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng GAO, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan^* (2020). Journal Article Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic Acids Research.