Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and the data analysis lead for the ICGC-ARGO Colorectal Cancer project. Leveraging his interdisciplinary expertise in computer science and oncology, Dr. Gao’s lab is dedicated to building the critical technical infrastructure for the “AI-Native Future Hospital.” By pioneering “AI Doctor 3.0” through multi-agent systems, multimodal foundation models, and intelligent surgical computing, his team is driving the paradigm shift from passive medical tools to autonomous, collaborative clinical intelligence. Using colorectal cancer as a flagship testing ground, Dr. Gao focuses on architecture-driven AI paradigms—rather than mere parameter scaling—to create full-stack, scalable solutions that fundamentally restructure healthcare supply and delivery.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics
City University of Hong Kong & Cornell University
2015 - 2018
Visiting Student in Computer Science and Electronic Engineering
Kumamoto University
2007 - 2008
BEng in Computer Science and Technology
Shandong University
2005 - 2009

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Feng GAO^†, William C Cho, Xin Gao, Wei Wang^* (2023). Journal Article Medical knowledge-assisted machine learning technologies in individualized medicine. Frontiers in Molecular Biosciences.

Fengao Wang^†, Junwei Liu, Feng GAO, Yixue Li^* (2023). Preprint Exploring multi-omics latent embedding spaces for characterizing tumor heterogeneity and tumoral fitness effects. bioRxiv.

Min-Er ZHONG^†, Xin DUAN^†, Ma-Yi-Di-Li Ni-Jia-Ti, Hao-Ning QI, Dong-Wei XU, Du CAI, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Feng GAO^*, Xiaojian Wu^* (2022). Journal Article CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study. Journal of Translational Medicine.

Chu-Ling HU^†, Du CAI, Min-Er ZHONG, De-Jun FAN, Cheng-Hang LI, Min-Yi LV, Ze-Ping HUANG, Wei Wang, Xiao-Jian Wu, Feng GAO^* (2022). Journal Article Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature. Frontiers in Genetics.

Feng GAO^†^*, Minhao Hu^†, Min-Er ZHONG^†, Shixiang Feng, Xuwei Tian, Xiaochun Meng, Ze-Ping HUANG, Min-Yi LV, Tao Song, Xiaofan Zhang^*, Xiangguang Zou^*, Xiaojian Wu^* (2022). Journal Article Segmentation only uses sparse annotations: Unified weakly and semi-supervised learning in medical images. Medical Image Analysis.

Min-Er ZHONG^†, Ze-Ping HUANG^†, Xun WANG^†, Du CAI, Cheng-Hang LI, Feng GAO^*, Xiao-Jian Wu^*, Wei Wang^* (2022). Journal Article A transcription factor signature can identify the CMS4 subtype and stratify the prognostic risk of colorectal cancer. Frontiers in Oncology.

Chu-Ling HU^†, Du CAI, Min-Er ZHONG, De-Jun FAN, Cheng-Hang LI, Min-Yi LV, Ze-Ping HUANG, Wei Wang, Xiaojian Wu, Feng GAO^* (2022). Conference Paper A tumor immune microenvironment-related lncRNA signature for the prognosis and immunotherapeutic sensitivity prediction in colorectal cancer.. Journal of Clinical Oncology.

Cheng-Hang LI^†, Du CAI, Min-Er ZHONG, Min-Yi LV, Ze-Ping HUANG, Qi-Qi ZHU, Chu-Ling HU, Hao-Ning QI, Xiaojian Wu, Feng GAO^* (2022). Journal Article Multi-size deep learning based preoperative computed tomography signature for prognosis prediction of colorectal cancer. Frontiers in Genetics.

Du CAI^†, Hao-Ning QI, Wei Wang, Min-Er ZHONG, De-Jun FAN, Cheng-Hang LI, Xiaojian Wu, Feng GAO^* (2022). Conference Paper PIANOS: A platform independent and normalization free single-sample classifier for colorectal cancer. Gastroenterology.

Qian Cai^†, Yi-Ze Mao^†, Si-Qi Dai^†, Feng GAO^†, Qian Xiao, Wan-Ming Hu, Tao Qin, Qiu-Xia Yang, Zhao-Zhou Li, Du CAI, Min-Er ZHONG, Ke-Feng Ding^*, Xiaojian Wu^*, Rong Zhang^* (2022). Journal Article The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study. European Radiology.

Xinkai Zhao^†, Chaowei Fang, De-Jun FAN, Xutao Lin, Feng GAO, Guanbin Li^* (2022). Conference Paper Cross-level contrastive learning and consistency constraint for semi-supervised medical image segmentation. IEEE International Symposium on Biomedical Imaging.

Min-Yi LV^†, Wei Wang^†, Min-Er ZHONG^†, Du CAI, De-Jun FAN, Cheng-Hang LI, Wei-Bin KOU, Ze-Ping HUANG, Xin DUAN, Chu-Ling HU, Qi-Qi ZHU, Xiao-Sheng He, Feng GAO^* (2022). Journal Article DNA Repair–Related Gene Signature in Predicting Prognosis of Colorectal Cancer Patients. Frontiers in Genetics.

Jinsei Miyoshi^†, Zhongxu Zhu^†, Aiping Luo^†, Shusuke Toden^†, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal M. Parker, Minjie Wang, Feng GAO, Ali H. Zaidi, Hideo Baba, Yasuhiro Kodera, Yongping Cui, Xin Wang^*, Zhihua Liu^*, Ajay Goel^* (2022). Journal Article A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study. Molecular Cancer.

Tongtong Kan^†, Shupeng Zhang, Shengtao Zhou, Ya Zhang, Yun Zhao, Yinghua Gao, Tao Zhang, Feng GAO, Xin Wang, Linjie Zhao, Mengsu Yang^* (2022). Journal Article Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence. Oncogene.

Xin DUAN^†, Wei Wang, Minghui Tang, Feng GAO^*, Xu-Dong Lin^* (2022). Journal Article Dissecting Cellular Heterogeneity Based on Network Denoising of scRNA-seq Using Local Scaling Self-Diffusion. Frontiers in Genetics.

Ruifei Zhang^†, Peiwen Lai, Xiang Wan, De-Jun FAN, Feng GAO, Xiao-Jian Wu, Guanbin Li^* (2022). Conference Paper Lesion-aware dynamic kernel for polyp segmentation. Lecture Notes in Computer Science.

Xu-Tao Lin^†, Qiu-Ning Wu, Si Qin, De-Jun FAN, Min-Yi LV, Xi Chen, Jia-Wei Cai, Jing-Rong Weng, Yi-Feng Zou, Yu-Ming Rong^*, Feng GAO^* (2021). Journal Article Identification of an autophagy-related gene signature for the prediction of prognosis in early-stage colorectal cancer. Frontiers in Genetics.

Yu-Feng Chen^†, Zhao-Liang Yu^†, Min-Yi LV^†, Ze-Rong Cai, Yi-Feng Zou, Ping Lan^*, Xiao-Jian Wu^*, Feng GAO^* (2021). Journal Article Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis. Molecular Medicine.

Raju Kandimalla^†, Wei Wang, Fan Yu, Nianxin Zhou, Feng GAO, Monique Spillman, Lucie Moukova, Ondrej Slaby, Bodour Salhia, Shengtao Zhou^*, Xin Wang^*, Ajay Goel^* (2021). Journal Article OCaMIR—a noninvasive, diagnostic signature for early-stage ovarian cancer: a multi-cohort retrospective and prospective study. Clinical Cancer Research.

Haoyang Li^†, Juexiao Zhou, Yi Zhou, Qiang Chen, Yangyang She, Feng GAO, Ying Xu, Jie-Yu CHEN, Xin Gao^* (2021). Journal Article An interpretable computer-aided diagnosis method for periodontitis from panoramic radiographs. Frontiers in Physiology.