Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and the data analysis lead for the ICGC-ARGO Colorectal Cancer project. Leveraging his interdisciplinary expertise in computer science and oncology, Dr. Gao’s lab is dedicated to building the critical technical infrastructure for the “AI-Native Future Hospital.” By pioneering “AI Doctor 3.0” through multi-agent systems, multimodal foundation models, and intelligent surgical computing, his team is driving the paradigm shift from passive medical tools to autonomous, collaborative clinical intelligence. Using colorectal cancer as a flagship testing ground, Dr. Gao focuses on architecture-driven AI paradigms—rather than mere parameter scaling—to create full-stack, scalable solutions that fundamentally restructure healthcare supply and delivery.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics
City University of Hong Kong & Cornell University
2015 - 2018
Visiting Student in Computer Science and Electronic Engineering
Kumamoto University
2007 - 2008
BEng in Computer Science and Technology
Shandong University
2005 - 2009

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Zhen Xie^†, Du CAI^†, Runyi Ye, Zhen Shan, Ying Lin, Feng GAO^*, Nan Shao^*, Xiaying Kuang^* (2024). Journal Article Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer. Gland Surgery.

Feng Guo^†, Xianglin Ji^†, Chuxiao Xiong, Hailiang Sun, Zhenghua Liang, Richard Yan-Do, Bao-Wen GAI, Feng GAO, Linfeng Huang, Zhongping Li, Becki Yi Kuang, Peng Shi^* (2024). Journal Article Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening. Nature Communications.

Jia-Xin LEI^†, Run-Xian WANG^†, Chu-Ling HU, Xiaoying Lou, Min-Yi LV, Cheng-Hang LI, Bao-Wen GAI, Xiao-Jian Wu^*, Ruoxu Dou^*, Du CAI^*, Feng GAO^* (2024). Journal Article Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study. International Journal of Surgery.

Feng-Ao Wang^†, Zhenfeng Zhuang^†, Feng GAO^†, Ruikun He, Shaoting Zhang, Liansheng Wang^*, Junwei Liu^*, Yixue Li^* (2024). Journal Article TMO-Net: an explainable pretrained multi-omics model for multi-task learning in oncology. Genome Biology.

Wei Lou^†, Xiang Wan, Guanbin Li, Xiaoying Lou, Cheng-Hang LI, Feng GAO, Haofeng Li^* (2024). Journal Article Structure Embedded Nucleus Classification for Histopathology Images. IEEE Transactions on Medical Imaging.

Xinkai Zhao^†, Chaowei Fang, De-Jun FAN, Xutao Lin, Feng GAO, Guanbin Li^* (2024). Conference Paper Cross-Level Contrastive Learning and Consistency Constraint for Semi-Supervised Medical Image Segmentation. IEEE International Symposium on Biomedical Imaging.

Nan Zhang^†^*, Wei Wang, Xin Gao, Feng GAO (2024). Journal Article Editorial: Clinical risk assessment and intervention of gastrointestinal tumors driven by big-data. Frontiers in Medicine.

Ngan Pan Bennett Au^†, Tan Wu, Xinyu Chen, Feng GAO, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H Geschwind, Giovanni Coppola, Xin Wang, Chi Him Eddie Ma^* (2023). Journal Article Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair. Neuron.

Jia Ke^†, Cheng Jin^†, Jinghua Tang^†, Haimei Cao^†, Songbing He^†, Peirong Ding, Xiaofeng Jiang, Hengyu Zhao, Wuteng Cao, Xiaochun Meng, Feng GAO, Ping Lan, Ruijiang Li^*, Xiaojian Wu^* (2023). Journal Article A Longitudinal MRI-Based Artificial Intelligence System to Predict Pathological Complete Response After Neoadjuvant Therapy in Rectal Cancer: A Multicenter Validation Study. Diseases of the Colon & Rectum.

Yanjiao Hua^†, Du CAI, Cole Andrea Shirley, Sien Mo, Ruyun Chen, Feng GAO, Fangying Chen^* (2023). Journal Article A prognostic model for ovarian neoplasms established by an integrated analysis of 1580 transcriptomic profiles. Scientific Reports.

Wentai Hou^†, Yan He, Bingjian Yao, Lequan Yu, Rongshan Yu, Feng GAO, Liansheng Wang^* (2023). Conference Paper Multi-scope Analysis Driven Hierarchical Graph Transformer for Whole Slide Image Based Cancer Survival Prediction. Medical Image Computing and Computer Assisted Intervention.

Lin Qi^†, Jie-Ying Liang^†, Zhong-Wu Li, Shao-Yan Xi, Yu-Ni Lai, Feng GAO, Xian-Rui Zhang, De-Shen Wang, Ming-Tao Hu, Yi Cao, Li-Jian Xu, Ronald C K Chan, Bao-Cai Xing, Xin Wang^*, Yu-Hong Li^* (2023). Journal Article Deep learning-derived spatial organization features on histology images predicts prognosis in colorectal liver metastasis patients after hepatectomy. iScience.

Yize Mao^†, Hui Xie^†, Min-Yi LV^†, Qiuxia Yang, Zeyu Shuang, Feng GAO, Shengping Li^*, Lina Zhu^*, Wei Wang^* (2023). Journal Article The landscape of objective response rate of anti-PD-1/L1 monotherapy across 31 types of cancer: a system review and novel biomarker investigating. Cancer Immunology, Immunotherapy.

Min-Yi LV^†, Du CAI^†, Cheng-Hang LI^†, Junguo Chen^†, Guanman Li, Chu-Ling HU, Bao-Wen GAI, Jia-Xin LEI, Ping Lan^*, Xiaojian Wu^*, Xiaosheng He^*, Feng GAO^* (2023). Journal Article Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies. MedComm.

Weiqiang You^†, Du CAI, Min-Yi LV, Peishan Hu, Feng GAO, Xiaojian Wu^* (2023). Conference Paper Immunological profiling of human colorectal cancer defines four distinct molecular subtypes. International Digestive Disease Forum.

Xin Wang^†, Yu-Hong Li, Baocai Xing, Lin Qi, Jie-Ying Liang, Zhong-Wu Li, Shao-Yan Xi, Yu-Ni Lai, Feng GAO, De-Shen Wang, Ming-Tao Hu, Yi Cao, Xian-Rui Zhang, Li-Jian Xu, Ronald CK Chan^* (2023). Conference Paper Deep learning-derived spatial organization features on histopathology images to predict prognosis in patients with colorectal liver metastasis, after hepatectomy.. Journal of Clinical Oncology.

Min-Yi LV^†, Du CAI, Cheng-Hang LI, Junguo Chen, Guanman Li, Chu-Ling HU, Bao-Wen GAI, Jia-Xin LEI, Ping Lan, Feng GAO, Xiaosheng He^* (2023). Conference Paper Senescence-Based Colorectal Cancer Subtyping Reveals Distinct Molecular Characteristics and Therapeutic Strategies. Gastroenterology.

Yuanyuan Guo^†, Xuantong Zhou, Feng GAO, Minjie Wang, Qi Yang, Xin Li, Zhihua Liu, Aiping Luo^* (2023). Journal Article MiR-423-5p is a novel endogenous control for the quantification of circulating miRNAs in human esophageal squamous cell carcinoma. Heliyon.

Du CAI^†, Wei Wang, Min-Er ZHONG, De-Jun FAN, Xuanhui Liu, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Min-Yi LV, Chu-Ling HU, Xin DUAN, Xiao-Jian Wu^*, Feng GAO^* (2023). Journal Article An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer. Cancer Medicine.

Feng GAO^†, William C. Cho^†, Xin Gao, Wei Wang^* (2023). Journal Article Editorial: Medical knowledge-assisted machine learning technologies in individualized medicine. Frontiers in Molecular Biosciences.