Feng GAO

Professor

Sun Yat-sen University

Biography

Dr. Feng Gao is a Professor of Medical AI at the Sixth Affiliated Hospital of Sun Yat-sen University and the data analysis lead for the ICGC-ARGO Colorectal Cancer project. Leveraging his interdisciplinary expertise in computer science and oncology, Dr. Gao’s lab is dedicated to building the critical technical infrastructure for the “AI-Native Future Hospital.” By pioneering “AI Doctor 3.0” through multi-agent systems, multimodal foundation models, and intelligent surgical computing, his team is driving the paradigm shift from passive medical tools to autonomous, collaborative clinical intelligence. Using colorectal cancer as a flagship testing ground, Dr. Gao focuses on architecture-driven AI paradigms—rather than mere parameter scaling—to create full-stack, scalable solutions that fundamentally restructure healthcare supply and delivery.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Joint PhD in Cancer Biology and Bioinformatics
City University of Hong Kong & Cornell University
2015 - 2018
Visiting Student in Computer Science and Electronic Engineering
Kumamoto University
2007 - 2008
BEng in Computer Science and Technology
Shandong University
2005 - 2009

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Chong Chen^†, Du CAI^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chu-Ling HU, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng GAO, Xiaojian Wu^*, Peishan Hu^* (2026). Journal Article Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma. Cell Death & Disease.

Bao-Wen GAI^†, Xin DUAN, Cheng-Hang LI, Chu-Ling HU, Min-Yi LV, Jia-Xin LEI, Run-Xian WANG, Feng GAO^*, Du CAI^* (2026). Journal Article Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer. Diagnostics.

Du CAI^†, Ming-Ru MAI^†, Ren-De HUANG^†, Hao-Ning QI, Xingzhi Feng, Qianling Gao, Yin-Meng ZHANG, Cheng-Hang LI, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng GAO^* (2025). Journal Article Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification. Cancer Science.

Haitao Xiang^†, Xiangyu Guan^†, Yaohua Wei^†, Shuzhen Luo^†, Haibo Zhang^†, Fanyu Bu, Yixin Yan, Yunyun Fu, Yijian Li, Qumiao Xu, Penghui Lin, Dongbing Liu, Xinlan Zhou, Feng GAO, Tai Chen, Guangjun Nie, Kui Wu, Ying Gu, Longqi Liu, Ziqing Ye^*, Xiaojian Wu^*, Ruifang Zhao^*, Siqi Liu^*, Xuan Dong^* (2025). Journal Article Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC. Cell Genomics.

Ke-Cheng WU^†, Zhaohu Xing, Zerong Cai, Feng GAO, Wenxue Li, Lei Zhu^* (2025). Conference Paper FSA-Net: Fractal-driven Synergistic Anatomy-aware Network for Segmenting White Line of Toldt in Laparoscopic Images. MICCAI.

Jing Yang^†, Yuxi Ma, Jin-Gang Yu, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang^*, Liansheng Wang^* (2025). Conference Paper Bridging Knowledge Discrepancy in Retinal Image Analysis through Federated Multi-Task Learning. MICCAI.

Riyu Qiu^†, Kun Xia, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang, Yinran Chen^*, Liansheng Wang^* (2025). Conference Paper Accurate Boundary Alignment and Realism Enhancement for Colonoscopic Polyp Image-Mask Pair Generation. MICCAI.

Zhengran Zhou^†, Richard Mortensen^†, Peishan Hu^†, Bo Jin, Xiao-Bin Zheng, Xiao Li, James Schilling, C. James Chou, Karl G. Sylvester, Yanghai Cong, Xiaojian Wu, Feng GAO^*, Xuefeng B. Ling^*, Xuanhui Liu^* (2025). Journal Article A plasma metabolite-based test to detect minimal residual disease in post-surgery patients with colorectal cancer. iScience.

Ren-De HUANG^†, Jiang Li^†, Qi Cao^†, Lixia Wang^†, Zhixiong Shao, Haochun Yang, Xinlei Zhang, Chuanlai Yang, Xiangya Kong, Qiuyue Gu, Jianmin Wu, Tsan-Yu Chiu, Penghu Lian^*, Kui Wu^*, Feng GAO^*, Zhongxu Zhu^* (2025). Journal Article PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers. NAR.

Code Project DOI

Yibin Zhao^†, Hao Liu^†, Yu Wang, Jie Shen, Yang Le, Peiyuan Li, Yuxiang Zhao^*, Feng GAO^*, Wei Cui^* (2025). Journal Article Immunological Microenvironment Differences Between Left and Right Colon Cancer: Dynamic Interactions of CASC15+KLK6+ Epithelial Subpopulation with T Cells and Mast Cells. IJS.

Chong-Xiang GAO^†, Du CAI, Jianguang Qiu^*, Feng GAO^* (2025). Journal Article The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target. Clin Transl Disc.

Jing Yang^†, Du CAI^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-Ao Wang, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng GAO^*, Xiaojian Wu^* (2025). Journal Article CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning. Advanced Science.

Du CAI^†, Hao-Ning QI^†, Qiuxia Yang^†, Huayu Li^†, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Xu Zhang, Yize Mao^*, Feng GAO^*, Xiaojian Wu^* (2025). Journal Article Personalized risk stratification in colorectal cancer via PIANOS system. Nature Communications.

Jia Ke^†, Ying Li^†, Lin Qi^†, Xiang Li, Wei Wang, Sanne Ten Hoorn, Yin Zhu, Hao Huang, Feng GAO, Louis Vermeulen, Xin Wang^* (2025). Journal Article Poor-prognosis young-onset colorectal cancer is defined by the mesenchymal subtype and can be predicted by integrating molecular and histopathological characteristics. ESMO Gastrointest Oncol.

Feng GAO^†, Junxiang Ding^†, Bao-Wen GAI^†, Du CAI^†, Chu-Ling HU, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^* (2025). Journal Article Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer. Advanced Science.

Xuefeng Zhang^†, Bin Yan, Zhaohu Xing, Feng GAO, Yuandong Tao, Zhenyan Han, Weiming Wang^*, Lei Zhu^* (2025). Journal Article HADiff: hierarchy aggregated diffusion model for pathology image segmentation. TVC.

Junwei Liu^†, Xiaoping Cen^†, Chenxin Yi, Feng-Ao Wang, Junxiang Ding, Jinyu Cheng, Qinhua Wu, Bao-Wen GAI, Yiwen Zhou, Ruikun He, Feng GAO^*, Yixue Li^* (2025). Journal Article Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis. Genomics Proteomics Bioinformatics.

Jinsei Miyoshi^†, Alessandro Mannucci^†, Marco Scarpa, Feng GAO, Shusuke Toden, Timothy Whitsett, Landon J Inge, Ross M Bremner, Tetsuji Takayama, Yulan Cheng, Teodoro Bottiglieri, Iris D Nagetaal, Martha J Shrubsole, Ali H Zaidi, Xin Wang, Helen G Coleman, Lesley a Anderson, Stephen J Meltzer, Ajay Goel^* (2025). Journal Article Liquid biopsy to identify Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma: the EMERALD multicentre study. Gut.

PMID Trial Registration Dataset DOI

Zhaohu Xing^†, Tian Ye, Yijun Yang, Du CAI, Bao-Wen GAI, Xiao-Jian Wu^*, Feng GAO^*, Lei Zhu^* (2025). Journal Article SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation. TMI.

Xinzhe Zhao^†, Hongda Zhang, Hengyu Zhao, Decan Kong, Weijie Zeng, Feng GAO, Xiaochun Meng, Jia Ke^* (2024). Journal Article Anatomic association between the gastrocolic trunk of Henle and right colic artery by high-quality CT venography. Scientific Reports.