Du CAI

Postdoc

Sun Yat-sen University

Biography

Dr. Du Cai, a postdoctoral researcher in the Department of Surgery at the Sixth Affiliated Hospital of Sun Yat-sen University, utilizes explainable AI (XAI) techniques and large foundation models in medical imaging and digital pathology to drive translational research in colorectal cancer.

Research Interests

Artificial Intelligence
Colorectal Cancer

Education

Doctor of Medicine in Surgery
Sun Yat-sen University
2018 - 2023
Bachelor of Medicine in Clinical Medicine
Sun Yat-sen University
2013 - 2018

Related Publications

† First or co-first author, * Corresponding or co-corresponding author, bold names are lab members

Chong Chen^†, Du CAI^†, Xuanhui Liu^†, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chu-Ling HU, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng GAO, Xiaojian Wu^*, Peishan Hu^* (2026). Journal Article Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma. Cell Death & Disease.

Bao-Wen GAI^†, Xin DUAN, Cheng-Hang LI, Chu-Ling HU, Min-Yi LV, Jia-Xin LEI, Run-Xian WANG, Feng GAO^*, Du CAI^* (2026). Journal Article Translating Molecular Subtypes into Cost-Effective Radiogenomic Biomarkers for Prognosis of Colorectal Cancer. Diagnostics.

Du CAI^†, Ming-Ru MAI^†, Ren-De HUANG^†, Hao-Ning QI, Xingzhi Feng, Qianling Gao, Yin-Meng ZHANG, Cheng-Hang LI, Xiaojian Wu^*, Yize Mao^*, Zihuan Yang^*, Feng GAO^* (2025). Journal Article Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification. Cancer Science.

Jing Yang^†, Yuxi Ma, Jin-Gang Yu, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang^*, Liansheng Wang^* (2025). Conference Paper Bridging Knowledge Discrepancy in Retinal Image Analysis through Federated Multi-Task Learning. MICCAI.

Riyu Qiu^†, Kun Xia, Feng GAO, Shu-Ting YANG, Du CAI, Jiacheng Wang, Yinran Chen^*, Liansheng Wang^* (2025). Conference Paper Accurate Boundary Alignment and Realism Enhancement for Colonoscopic Polyp Image-Mask Pair Generation. MICCAI.

Chong-Xiang GAO^†, Du CAI, Jianguang Qiu^*, Feng GAO^* (2025). Journal Article The role of tertiary lymphoid structures in renal cell carcinoma: From predictive biomarker to therapeutic target. Clin Transl Disc.

Jing Yang^†, Du CAI^†, Junwei Liu^†, Zhenfeng Zhuang^†, Yibin Zhao, Feng-Ao Wang, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Yiping Chen, Yixue Li, Liansheng Wang^*, Feng GAO^*, Xiaojian Wu^* (2025). Journal Article CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning. Advanced Science.

Du CAI^†, Hao-Ning QI^†, Qiuxia Yang^†, Huayu Li^†, Cheng-Hang LI, Chu-Ling HU, Bao-Wen GAI, Xu Zhang, Yize Mao^*, Feng GAO^*, Xiaojian Wu^* (2025). Journal Article Personalized risk stratification in colorectal cancer via PIANOS system. Nature Communications.

Feng GAO^†, Junxiang Ding^†, Bao-Wen GAI^†, Du CAI^†, Chu-Ling HU, Feng-Ao Wang, Ruikun He, Junwei Liu^*, Yixue Li^*, Xiao-Jian Wu^* (2025). Journal Article Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer. Advanced Science.

Zhaohu Xing^†, Tian Ye, Yijun Yang, Du CAI, Bao-Wen GAI, Xiao-Jian Wu^*, Feng GAO^*, Lei Zhu^* (2025). Journal Article SegMamba-V2: Long-range Sequential Modeling Mamba For General 3D Medical Image Segmentation. TMI.

Zhen Xie^†, Du CAI^†, Runyi Ye, Zhen Shan, Ying Lin, Feng GAO^*, Nan Shao^*, Xiaying Kuang^* (2024). Journal Article Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer. Gland Surgery.

Jia-Xin LEI^†, Run-Xian WANG^†, Chu-Ling HU, Xiaoying Lou, Min-Yi LV, Cheng-Hang LI, Bao-Wen GAI, Xiao-Jian Wu^*, Ruoxu Dou^*, Du CAI^*, Feng GAO^* (2024). Journal Article Deciphering Tertiary Lymphoid Structure Heterogeneity Reveals Prognostic Signature and Therapeutic Potentials for Colorectal Cancer: A Multicenter Retrospective Cohort Study. International Journal of Surgery.

Yanjiao Hua^†, Du CAI, Cole Andrea Shirley, Sien Mo, Ruyun Chen, Feng GAO, Fangying Chen^* (2023). Journal Article A prognostic model for ovarian neoplasms established by an integrated analysis of 1580 transcriptomic profiles. Scientific Reports.

Min-Yi LV^†, Du CAI^†, Cheng-Hang LI^†, Junguo Chen^†, Guanman Li, Chu-Ling HU, Bao-Wen GAI, Jia-Xin LEI, Ping Lan^*, Xiaojian Wu^*, Xiaosheng He^*, Feng GAO^* (2023). Journal Article Senescence-based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies. MedComm.

Weiqiang You^†, Du CAI, Min-Yi LV, Peishan Hu, Feng GAO, Xiaojian Wu^* (2023). Conference Paper Immunological profiling of human colorectal cancer defines four distinct molecular subtypes. International Digestive Disease Forum.

Min-Yi LV^†, Du CAI, Cheng-Hang LI, Junguo Chen, Guanman Li, Chu-Ling HU, Bao-Wen GAI, Jia-Xin LEI, Ping Lan, Feng GAO, Xiaosheng He^* (2023). Conference Paper Senescence-Based Colorectal Cancer Subtyping Reveals Distinct Molecular Characteristics and Therapeutic Strategies. Gastroenterology.

Du CAI^†, Wei Wang, Min-Er ZHONG, De-Jun FAN, Xuanhui Liu, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Min-Yi LV, Chu-Ling HU, Xin DUAN, Xiao-Jian Wu^*, Feng GAO^* (2023). Journal Article An immune, stroma, and epithelial--mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II--III colorectal cancer. Cancer Medicine.

Min-Er ZHONG^†, Xin DUAN^†, Ma-Yi-Di-Li Ni-Jia-Ti, Hao-Ning QI, Dong-Wei XU, Du CAI, Cheng-Hang LI, Ze-Ping HUANG, Qi-Qi ZHU, Feng GAO^*, Xiaojian Wu^* (2022). Journal Article CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study. Journal of Translational Medicine.

Chu-Ling HU^†, Du CAI, Min-Er ZHONG, De-Jun FAN, Cheng-Hang LI, Min-Yi LV, Ze-Ping HUANG, Wei Wang, Xiao-Jian Wu, Feng GAO^* (2022). Journal Article Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature. Frontiers in Genetics.

Min-Er ZHONG^†, Ze-Ping HUANG^†, Xun WANG^†, Du CAI, Cheng-Hang LI, Feng GAO^*, Xiao-Jian Wu^*, Wei Wang^* (2022). Journal Article A transcription factor signature can identify the CMS4 subtype and stratify the prognostic risk of colorectal cancer. Frontiers in Oncology.